| 摘要: |
| 抗N-甲基-D-天冬氨酸受体(N-methyl-D-aspartate receptor,NMDAR)脑炎是由靶向NMDAR GluN1 亚基的IgG 抗体所介导的自身免疫性脑炎,约占自身免疫性脑炎的80%,多见于青少年和年轻女性。患者通常会出现精神行为异常、语言障碍、癫痫发作、运动障碍、意识水平下降、自主神经功能障碍或中枢性通气不足等六大临床表现。虽然80%以上患者远期预后良好,但是该病康复过程漫长且多变,病死率为5% ~7% 。此外,通气不足及血压不稳定等自主神经功能紊乱可能在病程后期出现,并有造成长期及严重后遗症的风险。目前该病的治疗方案尚无统一标准,临床医师通常通过个人经验来判断是等待一线免疫治疗的反应还是立即转向更积极地免疫治疗。 |
| 关键词: |
| DOI：10.13407/j.cnki.jpp.1672-108X.2023.07.015 |
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| 基金项目: |
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| Progress of Cerebrospinal Fluid Biochemical Markers of Anti-N-Methyl-D-Aspartate Receptor Encephalitis |
| Ding Xiao, Jiang Li |
| (Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health
and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics,
Chongqing 400014, China) |
| Abstract: |
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