| 摘要: |
| 目的:通过对2 岁以下肝移植受者伏立康唑的应用现状进行回顾性分析,为临床药师深入开展药学监护提供有效的切入点和工作思路。方法:对2017-2019 年某院2 岁以下肝移植患儿应用伏立康唑的情况进行调查和分析。结果:126 例患儿使用伏立康唑预防或治疗侵袭性真菌病,初始剂量为4~6 mg/ kg,每日2 次,不良反应发生率为0. 79%。96 例治疗性用药患儿的总有效率为96. 8%,30 例预防性用药患儿的预防成功率为86. 67%。结论:临床药师可以根据循证证据从初始用药剂量、血药浓度监测、用药剂量调整、重点指标的综合评估等方面加强药学监护,提供用药建议,并开展科研工作。 |
| 关键词: 伏立康唑 儿童 肝移植 临床药师 药学监护 |
| DOI：10.13407/j.cnki.jpp.1672-108X.2023.01.004 |
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| 基金项目: |
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| Analysis of Pharmaceutical Care on the Use of Voriconazole in Pediatric Liver Transplantation Patients Younger Than 2 Years of Age |
| Wang Weina, Cheng Sheng, Wei Hongtao, Shen Su |
| (Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China) |
| Abstract: |
| Objective: To provide effective points and ideas of pharmaceutical care for clinical pharmacists through retrospective
analysis on the use of voriconazole in liver transplantation recipients under 2 years old. Methods: The application of voriconazole in liver
transplantation recipients under 2 years old from 2017 to 2019 was investigated and analyzed. Results: In 126 patients, voriconazole was
used to prevent or treat invasive fungal disease. The initial dose of voriconazole was 4-6 mg/ kg, twice a day, with incidence of adverse
reactions of 0. 79%. The total therapeutic effective rate in 96 patients with therapeutic administration was 96. 8%, and the success rate
of prevention in 30 patients with prophylactic administration was 86. 67%. Conclusion: Clinical pharmacists can provide evidence-based
pharmaceutical suggestions and scientific propaganda by carrying out pharmaceutical care from initial dosage, blood concentration
monitoring, dosage adjustment and comprehensive evaluation of key indicators, and scientific research. |
| Key words: voriconazole children liver transplantation clinical pharmacist pharmaceutical care |
