| 摘要: |
| 目的:调查我国儿科质子泵抑制剂(PPIs) 使用现状及存在问题,为儿童合理应用PPIs 提供参考。方法:采用文本分析
法,根据药品说明书、国内外临床诊疗指南/ 共识及文献资料编写PPIs 儿科临床使用情况调查问卷,在全国六大行政区20 个省
市的24 家医院发放问卷,并对调查结果进行统计分析。结果:共回收185 份有效调查问卷,24 家医院中21 家使用奥美拉唑注
射剂型,18 家使用奥美拉唑口服剂型,8 家使用艾司奥美拉唑口服剂型。较常见使用PPIs 的疾病为消化道溃疡、幽门螺杆菌感
染和胃食管反流病及反流性食管炎;存在超说明书适应证用药的调查问卷共156 份(84.32%);儿童剂量在诊疗指南/ 共识推荐
范围外的调查问卷96 份(51.89%);与抗菌药物、胃黏膜保护剂、H2 受体拮抗剂和微生态制剂等药物联合使用的调查问卷159
份(85.95%);PPIs 曾发生不良反应的问卷为136 份(73.51%)。结论:PPIs 在我国用于儿童属于超说明书用药,儿科临床超说
明书适应证用药以及诊疗指南/ 共识推荐的儿童剂量范围外用药的发生率较高,应规范临床医师处方行为,促进临床合理用药。
同时应鼓励制药企业完善药品说明书中儿童用药信息,保证其用药的安全性和有效性。 |
| 关键词: 质子泵抑制剂 儿科 临床应用 调查问卷 |
| DOI：doi:10.13407/ j.cnki.jpp.1672.108X.2022.04.003 |
|
| 基金项目:黑龙江省卫生健康委科研课题, 编号2020-041。 |
|
| Investigation and Analysis of Clinical Application of Proton Pump Inhibitors in Pediatrics in China |
| Wei Ting1 , Liu Bin1 , Zeng Qingwei1 , Zhang Li1 , Tong Yan1 , Yang Ning1 , Wang Xiaoling2 |
| (1. Harbin Children's
Hospital, Harbin 150010, China; 2. Beijing Children's Hospital, Capital Medical University, Beijing 100045, China) |
| Abstract: |
| Objective: To investigate the current status and problems of proton pump inhibitors (PPIs) in pediatrics in China, so as to
provide reference for the rational use of PPIs in children. Methods: The questionnaire on clinical use of PPIs in pediatrics was compiled
according to the drug instructions, clinical guidelines/ consensus, and literature at home and abroad. The questionnaire was distributed to
24 hospitals in 20 provinces and cities of 6 administrative regions in China, and the survey results were statistically analyzed. Results:
A total of 185 valid questionnaires were collected. Among the 24 hospitals, 21 used omeprazole (injection form), 18 used omeprazole
(oral dosage form), and 8 used esomeprazole (oral dosage form). Peptic ulcer, Helicobacter pylori infection, gastroesophageal reflux
disease and reflux esophagitis were the common diseases treated with PPIs. A total of 156 questionnaires (84郾32%) were found to have
off鄄label drug use. There were 96 questionnaires (51郾89%) with off鄄label recommended range of diagnosis and treatment guidelines/
consensus. Totally 159 questionnaires (85郾95%) had drug combination with antibiotics, gastric mucosal protective agents, H2 receptor
antagonists and probiotics. There were 136 questionnaires (73郾51%) with adverse drug reactions to PPIs. Conclusion: PPIs used in
children in China belongs to off鄄label drug use, and the incidence of off鄄label drug use in pediatrics and off鄄label dose recommended by
the diagnosis and treatment guidelines/ consensus is relatively high. Therefore, clinicians爷prescription behavior should be standardized
to promote clinical rational drug use. Meanwhile, pharmaceutical enterprises should be encouraged to improve the drug information for
children in the drug instructions to ensure the safety and effectiveness of drug use. |
| Key words: proton pump inhibitors pediatrics clinical application questionnaires |
