| 摘要: |
| [摘要]目的：评价拉考沙胺（LCM）在儿童癫痫的应用价值。方法：采用回顾性研究方法，对诊断为癫痫并接受LCM治疗的58例患儿进行分析。记录开始LCM治疗后3个月、6个月和12个月的癫痫发作频率，并与基线月度频率进行比较，评价患儿的临床疗效并观察不良反应。结果：患儿维持期LCM用量2.82~20.00（7.03±2.90）mg/（kg·d）。末次就诊40例（69.0%）患儿对LCM治疗有反应，表现出癫痫发作频率减少≥50%。癫痫完全控制率随着时间的推移而增加，在3、6、12个月时分别为15.5%、20.7%、24.1%。无效组异常脑电图患儿比例高于有效组（P均<0.05）。联合使用抗癫痫药物的数量越少，LCM添加得越早，儿童实现癫痫完全缓解的可能性就越高（P<0.05）。20例（34.5%）患儿至少经历了1次不良反应，常见不良反应为头晕、嗜睡、乏力和恶心呕吐。结论：LCM治疗癫痫发作患儿临床有效，且不良反应轻，耐受性好。 |
| 关键词: 拉考沙胺 癫痫 儿童 有效性 安全性 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2022.05.009 |
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| 基金项目:新疆维吾尔自治区人民医院院内科研基金资助项目,编号20190315。 |
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| Efficacy and Safety of Lacosamide in the Treatment of Children with Epilepsy |
| Yu Jing1, Zhao Ting2, Li Hongjian2, Ma Long1, Sun Yan1 |
| (1. Children’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, China; 2. People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, China) |
| Abstract: |
| [Abstract] Objective: To evaluate the clinical efficacy and safety of lacosamide (LCM) in the treatment of children with epilepsy. Methods: Fifty-eight children diagnosed with epilepsy and treated with LCM were retrospectively analyzed. The epilepsy frequencies of 3 months, 6 months and 12 months after the start of LCM treatment were recorded and compared with the baseline monthly frequency. The clinical efficacy and adverse drug reactions were evaluated. Results: The dosage of LCM during the maintenance period was from 2.82 to 20.00 (7.03±2.90) mg/(kg·d). Forty children (69.0%) at the last visit responded to LCM treatment, demonstrating more than or equal to 50% reduction in epilepsy frequencies. The rate of complete control of epilepsy increased over time, respectively 15.5%, 20.7% and 24.1% at 3, 6 and 12 months. The proportion of abnormal electroencephalogram in the ineffective group was significantly higher than that in the effective group (P<0.05). The less the number of combined use of anti-seizure medications and the earlier the addition of LCM, the higher the possibility of complete remission of epilepsy (P<0.05). Twenty (34.5%) children had at least one adverse drug reaction, and the common adverse drug reactions were dizziness, somnolence, fatigue and nausea and vomiting. Conclusion: LCM is clinically effective in the treatment of children with epilepsy, with mild adverse drug reactions and good tolerance. |
| Key words: lacosamide epilepsy children efficacy safety |
