| 摘要: |
| 目的：评价中文版Morisky用药依从性问卷（MMAS-8）在肾病综合征（NS）患儿中应用的信度和效度，探讨本地区NS患儿的用药依从性水平及影响因素。方法：应用中文版MMAS-8对就诊于我院的90例NS患儿开展用药依从性问卷调查。选用Cronbach α系数评价中文版MMAS-8内部一致性信度，组内相关系数（ICC）评价重测信度；选用主成分因子分析法评价结构效度；选用Pearson相关系数评价MMAS-8得分与6个月内复发次数的相关性；对NS患儿的用药依从性影响因素选用多因素多分类有序Logistic回归方法分析。结果：中文版MMAS-8的Cronbach α系数为0.751；ICC为0.865（P<0.05）；主成分因子分析共提取3个公共因子；调查的90例患儿中有78.89%的患儿用药依从性不佳（评分<8分）；患儿6个月内复发次数与MMAS-8得分存在中度的负相关（Pearson相关系数为-0.454，P<0.01）；用药依从性影响因素分析结果显示，病程<1年较病程>3年患儿的用药依从性好（P<0.05），由父母监督服药较自行服药的患儿用药依从性好（P<0.05），患儿及家属对疾病了解越多用药依从性越好（P<0.05）。年龄、性别、复发次数对服药依从性无显著影响（P>0.05）。结论：中文版MMAS-8具有较好的信度和效度，可用于评估NS患儿的用药依从性。本地区NS患儿用药依从性水平不高，与患儿病程、用药监护人、是否了解疾病基本知识有关。 |
| 关键词: 肾病综合征 用药依从性 Morisky用药依从性量表 信效度 影响因素 |
| DOI：doi:10.13407/ j.cnki. jpp.1672-108X.2022.06.007 |
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| 基金项目:郴州市第一人民医院院内科研项目,编号N2020-28;郴州市技术创新引导项目,编号lcyl2021077 |
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| Reliability and Validity Evaluation and Application of the Chinese Version of Morisky Medication Adherence Scale in Children with Nephrotic Syndrome |
| He Zhenji, Chen Bi, Li Hui, Yang Du, Li Wei |
| (Chenzhou First People’s Hospital, Hunan Chenzhou 423000, China) |
| Abstract: |
| Objective: To evaluate the reliability and validity of the Chinese version of Morisky medication adherence scale (MMAS-8) in children with nephrotic syndrome (NS), and to explore the medication adherence level and influencing factors of children with NS in this region. Methods: The Chinese version of MMAS-8 was used to investigate the medication adherence of 90 children with NS in our hospital. Cronbach α coefficient was used to evaluate the internal consistency reliability of the Chinese version of MMAS-8, the intra-group correlation coefficient (ICC) was used to evaluate the test-retest reliability, the principal component factor analysis method was used to evaluate the structural validity. Pearson correlation coefficient was used to evaluate the correlation between MMAS-8 score and the number of recurrences within 6 months. Influencing factors of medication adherence in children with NS were analyzed by multi-factor ordered multi-class Logistic regression. Results: The Cronbach α coefficient of the Chinese version of MMAS-8 was 0.751, the ICC was 0.865 (P<0.05). Three common factors were extracted by principal component factor analysis, 78.89% of the 90 children surveyed had poor medication adherence (<8 points). There was moderate negative correlation between the number of recurrences within 6 months and the score of MMAS-8 (Pearson correlation was -0.454, P<0.01). Results of influencing factors of medication adherence showed that children with disease course less than 1 year had better medication adherence than those with the course of disease more than 3 years (P<0.05), children with parental supervision had better medication adherence than those with self-medication (P<0.05), and the more the children and their families knew about the disease, the better the medication adherence (P<0.05). Age, gender and number of recurrences had no statistical significance on medication adherence (P>0.05). Conclusion: The Chinese version of MMAS-8 has good reliability and validity, and can be used to assess the medication adherence of children with NS. The level of medication adherence of children with NS in this area is not high, which is related to the course of disease, guardian of medication and basic knowledge of the disease. |
| Key words: nephrotic syndrome medication adherence Morisky medication adherence scale reliability and validity influencing factors |
