| 摘要: |
| 目的:系统评价维生素 D 受体(VDR)基因多态性与儿童龋病易感性的关联性。 方法:计算机检索中国知网、万方、中国生物医学文献数据库和 PubMed、EMBase、the Cochrane Library、Web of Science 数据库,搜集 VDR 基因多态性与儿童龋病易感性相关的病例对照研究,检索时限从建库至 2021 年 9 月。 由 2 名研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,
采用 Stata 15. 0 软件进行 Meta 分析。 结果:共纳入 6 个病例对照研究,包括病例组 1 160 例、对照组 827 例。 Meta 分析结果显示,VDR 基因 TaqI rs731236 多态性[tt+Tt vs. TT(OR= 0. 66,95%CI 0. 47 ~ 0. 92,P = 0. 013);Tt vs. TT(OR = 0. 66,95%CI 0. 47 ~0. 92,P = 0. 013)],FokI rs10735810 多态性[f vs. F(OR = 0. 75,95%CI 0. 59 ~ 0. 97,P = 0. 027);ff vs. Ff+FF(OR = 0. 54,95%CI0. 33~0. 87,P = 0. 011);ff vs. FF(OR= 0. 52,95%CI 0. 29~0. 92,P = 0. 025)]均与儿童龋病易感性存在显著相关性。 结论:当前证据表明 VDR TaqI、FokI 基因多态性与亚洲儿童龋病易感性存在显著关联。 受纳入研究数量及质量的限制,上述结论还需要更多高质量、大样本量的回顾性研究予以验证。 |
| 关键词: 维生素 D 受体 基因多态性 儿童龋病 Meta 分析 病例对照研究 |
| DOI：10.13407/j.cnki.jpp.1672-108X.2023.09.005 |
|
| 基金项目: |
|
| Meta-Analysis on Association between Vitamin D Receptor Gene Polymorphism and Dental Caries Susceptibility in Children |
| Yuan Xiyu1, Han Jing1, Cong Zhaoxia1, Zhao Jin1,2 |
| (1. The First Affiliated Hospital of Xinjiang Medical University / Stomatological Hospital, Urumqi 830054, China; 2. Xinjiang Uygur Autonomous Region Institute of Stomatology, Urumqi 830054, China) |
| Abstract: |
| Objective: To systematically evaluate the correlation of vitamin D receptor (VDR) gene polymorphism and dental caries susceptibility in children. Methods: CNKI, Wanfang, CBM, PubMed, EMBase, the Cochrane Library, Web of Science databases were retrieved to collect the case control study of VDR gene polymorphism and dental caries susceptibility in children. The retrieval time was from the establishment of the database to Sept. 2021. Stata 15. 0 software was used for Meta-analysis after two researchers independently
screened literature, extracted data, and evaluated the risk of bias in included literature. Results: A total of 6 case-control studies were enrolled, including 1,160 cases in the case group and 827 cases in the control group. Meta-analysis results showed that vitamin D receptor gene TaqI rs731236 polymorphism (tt+Tt vs. TT OR= 0. 66, 95%CI from 0. 47 to 0. 92, P = 0. 013; Tt vs. TT OR= 0. 66, 95% CI from 0. 47 to 0. 92, P = 0. 013), FokI rs10735810 polymorphism (f vs. F OR= 0. 75, 95%CI from 0. 59 to 0. 97, P = 0. 027; ff vs. Ff+FF OR = 0. 54, 95% CI from 0. 33 to 0. 87, P = 0. 011; ff vs. FF OR = 0. 52, 95% CI from 0. 29 to 0. 92, P = 0. 025) were significantly correlated with dental caries susceptibility in children. Conclusion: Current evidence shows that VDR TaqI and FokI gene polymorphisms are significantly correlated with dental caries susceptibility in Asian children. Limited by the number and quality of included studies, the above conclusions need to be verified by more high-quality, large-sample retrospective studies |
| Key words: vitamin D receptor gene polymorphism dental caries in children Meta-analysis case control study |
