| 摘要: |
| 目的:探讨儿童应用万古霉素引起药物热的临床特点,为临床安全合理用药提供参考。 方法:收集华中科技大学同济医学院附属武汉儿童医院 2017 年 7 月至 2021 年 6 月应用万古霉素引起药物热的住院患儿,并对国内儿童使用万古霉素引起药物热的病例报道进行文献复习,总结用药剂量、药物热发生时间、不良反应处理及转归情况。 结果:共收集万古霉素引起药物热的患儿 11 例,其中我院 4 例,文献报道 7 例。 药物热发热时间 5. 0(2. 0~10. 0)d,最高体温 39. 1(38. 3~40. 0)℃ ,停药后退热时间1. 9(1. 0~3. 0)d,可伴随其他器官和全身不良反应,发热期间实验室检查结果未见感染指标明显升高,停药后预后良好。 结论:万古霉素引起儿童药物热与感染性疾病的发热较难鉴别,应结合药物使用时间、实验室检查结果及患儿发热特点加以判断,及时停用可疑药物,避免出现严重不良反应。 |
| 关键词: 万古霉素 药物热 儿童 |
| DOI：10. 13407/ j. cnki. jpp. 1672-108X. 2023. 07. 004 |
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| 基金项目: |
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| Eleven Cases of Vancomycin-Induced Drug Fever in Children and Literature Review |
| Peng Jing, Xu Hua, Li Xinlin, Li Qiaoling |
| (Wuhan Children’s Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430016, China) |
| Abstract: |
| Objective: To investigate the clinical characteristics of vancomycin-induced drug fever in children, so as to provide reference for the safety of clinical drug use. Methods: Children with vancomycin-induced drug fever admitted into Wuhan Children’ s Hospital, Tongji Medical College, Huazhong University of Science & Technology from Jul. 2017 to Jun. 2021 were collected. Literature
review was conducted on the case reports of vancomycin-induced drug fever in children in China, and the drug dosage, duration, adverse drug reaction symptoms and outcomes were summarized. Results: A total of 11 children with vancomycin-induced drug fever were enrolled, including 4 cases in our hospital and 7 cases reported in literature. The duration of drug fever was 5. 0 (from 2. 0 to 10. 0) d,
the maximum body temperature was 39. 1 (from 38. 3 to 40. 0) ℃ , and the duration of fever remission was 1. 9 (from 1. 0 to 3. 0) d, which could be accompanied by other organs and systemic adverse drug reactions. No significant increase of infection indicators was found in laboratory tests during fever, and the prognosis was good after drug withdrawal. Conclusion: Vancomycin-induced drug fever in children is difficult to distinguish from fever of infectious diseases, so it should be judged by the time of drug use, laboratory test results and fever characteristics of the children, and the suspected drug should be stopped in time to avoid severe adverse drug reactions. |
| Key words: vancomycin drug fever children |
