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| 质量改进方案降低早产儿疑似早发败血症抗菌药物使用率 |
| 杨朦1,2,杨树杰1,2,甘斌1,易海英1,张萍1,李磊1 |
|
|
| ((1. 武汉科技大学附属孝感医院,湖北孝感 432000;2. 武汉科技大学医
学院,武汉 430065)) |
|
| 摘要: |
| 目的:探讨质量改进方案降低早产儿疑似早发败血症( EOS) 抗菌药物使用率的临床效果。方法:制订早产儿疑似EOS
抗菌药物使用临床质量改进方案,采用队列研究方法,选择2019 年10 月至2020 年12 月我院新生儿科收治的早产儿疑似EOS
患儿为观察组,收集2018 年6 月至2019 年6 月收治的早产儿疑似EOS 患儿为对照组。抗菌药物使用率、抗菌药物使用时间和
感染反复情况为主要观察指标。结果:纳入研究的早产儿572 例,其中观察组242 例,对照组330 例,两组患儿一般资料比较差
异均无统计学意义(P>0. 05)。观察组早产儿疑似EOS 抗菌药物使用率75. 98%,低于对照组的89. 69%;对照组每千住院日抗
菌药物使用时间为329. 11 d,长于观察组的216. 05 d。两组均无死亡病例,住院期间停用抗菌药物后患儿感染相关的不良事件
发生情况比较差异无统计学意义(P>0. 05)。结论:质量改进方案可减少早产儿疑似EOS 抗菌药物的使用率和使用时间。本研
究可为早产儿抗菌药物的合理使用提供参考。 |
| 关键词: 败血症 疑似 抗菌药物 质量改进 早产儿 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2023.02.009 |
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| 基金项目:2019 年度孝感市自然科学计划项目,编号XGKJ2019010011。 |
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| Effect of Quality Improvement on the Utilization Rate of Antibacteria Drug in Premature Infants Suspectedof Early-onset Sepsis |
| Yang Meng1,2, Yang Shujie1,2, Gan Bin1, Yi Haiying1, Zhang Ping1, Li Lei1 |
| ((1. Xiaogan Hospital, Wuhan University of
Science and Technology, Hubei Xiaogan 432000, China;2. School of Medicine, Wuhan University of Science and Technology, Wuhan
430065, China)) |
| Abstract: |
| Objective: To investigate the clinical effect of quality improvement on the utilization rate of antibacteria drug in premature
infants suspected of early-onset sepsis (EOS). Methods: The clinical quality improvement program for the use of antibacteria drug in
premature infants suspected of EOS was formulated, and cohort study was adopted. Children with suspected EOS in preterm infants
admitted to the neonatal department of our hospital from October 2019 to December 2020 were selected as the observation group, and children with suspected EOS in preterm infants admitted from June 2018 to June 2019 were selected as the control group. The main
outcome measures were antibacteria drug utilization rate, duration of antibacteria drug use, and recurrence of infection. Results:The
study included 572 preterm infants, the observation group included 242 cases, and the control group included 330 cases. There was no
significant difference in the clinical general data in the two groups (P>0. 05). The utilization rate of antibacteria drug in the observation
group (75. 98%) was lower than that in the control group (89. 69%). The antibacteria drug use time of the control group (329. 11 days
per 1,000 hospital days) was higher than that in the observation group (216. 05 days per 1,000 hospital days). There was no death in
the two groups. There was either no significant difference in infection-related adverse events after antibacteria drug discontinuation during
hospitalization (P>0. 05). Conclusion: Quality improvement can reduce the utilization rate and duration of suspected EOS antibacteria
drug in preterm infants, providing theoretical basis for rational use of antibacteria drug in preterm infants. |
| Key words: sepsis suspected antibacteria drug quality improvement preterm infant |
