| 摘要: |
| 目的：探讨13种儿科常用抗菌药物与小儿电解质补给注射液的配伍稳定性。方法：模拟临床用药，考察13种儿科常用抗菌药物与小儿电解质补给注射液配伍后的外观、性状、pH和主要成分相对含量变化情况。结果：头孢呋辛钠、头孢他啶、头孢曲松钠、头孢美唑钠、哌拉西林钠/他唑巴坦钠、拉氧头孢钠、亚胺培南/西司他丁钠、美罗培南与小儿电解质补给注射液配伍后0~4 h内其外观、可见异物、pH和主要成分相对含量均无明显变化；万古霉素、阿奇霉素、阿米卡星、伏立康唑、头孢哌酮钠/舒巴坦钠与小儿电解质补给注射液配伍后0~8 h内其外观、性状、pH和主要成分相对含量均无明显变化。结论：头孢呋辛钠、头孢他啶、头孢曲松钠、头孢美唑钠、哌拉西林钠/他唑巴坦钠、拉氧头孢钠、亚胺培南/西司他丁钠、美罗培南、万古霉素、阿奇霉素、阿米卡星、伏立康唑、头孢哌酮钠/舒巴坦钠与小儿电解质补给注射液配伍良好 |
| 关键词: 小儿电解质补给注射液 抗菌药物 配伍稳定性 |
| DOI：10.13407/j.cnki.jpp.1672-108X.2022.11.006 |
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| 基金项目:北京儿童健康基金会药学学科建设专项子项目,编号BCHF2020KY001 |
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| Compatible Stability of 13 Kinds of Commonly Used Antibiotics Injections and Pediatric Electrolyte Supplements Injection |
| Wei Xia1, Li Ying2, Cheng Qing2, Lu Qinghong1, Wang Xiaoling2 |
| (1. Jiangxi Provincial Children’s Hospital, Nanchang 360000, China; 2. National Center for Children’s Health, Beijing Children’s Hospital, Capital Medical University, Beijing 100045, China) |
| Abstract: |
| Objective: To probe into the compatible stability of 13 kinds of commonly used antibiotics injections and pediatric electrolyte supplements injection. Methods: The appearance, characteristics, pH and relative content of main components of 13 kinds of commonly used pediatric antibiotics combined with pediatric electrolyte supplement injection were investigated by simulating clinical medication. Results: Cefuoxime sodium, ceftazidime, ceftriaxone sodium, cefmetazole sodium, piperacillin sodium/tazobactam sodium, latamoxef sodium, imipenem/cilastatin sodium and meropenem had no significant changes in appearance, characteristics, pH and relative content of main components within 4 h after the combination with pediatric electrolyte supplements injection. Vancomycin, azithromycin, amikacin, voriconazole, cefoperazone sodium/sulbactam sodium had no significant changes in appearance, characteristics, pH and relative content of main components within 8 h after the combination with pediatric electrolyte supplements injection. Conclusion: Cefuroxime sodium, ceftazidime, ceftriaxone sodium, cefmetazole sodium, piperacillin sodium/tazobactam sodium, laoxycef sodium, imipenem/cilastatin sodium, meropenem, vancomycin, azithromycin, amikacin, voriconazole, cefoperazone sodium/sulbactam sodium are well compatible with pediatric electrolyte supplements injection |
| Key words: pediatric electrolyte supplements injection antibiotics compatible stability |
