| 摘要: |
| 目的:借助中国医院药物警戒系统(CHPS)的真实世界数据,评价某院儿童使用头孢唑肟的安全性,并分析头孢唑肟相
关药物不良反应(ADR)发生情况及影响因素。方法:基于CHPS 平台,对我院2018 年2 月至2020 年4 月使用头孢唑肟的住院
患儿进行单中心回顾性主动监测,药师对系统监测病例进行评定,获得头孢唑肟 ADR 发生率,并对ADR 影响因素进行分析。
结果:系统共回顾性监测了2 948 例使用头孢唑肟的患儿,31 例出现ADR,ADR 发生率为1. 09%。多因素logistic 回归分析显
示,头孢唑肟联合氟氯西林、单次用药剂量是儿童使用头孢唑肟发生ADR 的独立影响因素。结论:头孢唑肟在儿童用药中发生
ADR 并不少见。减少与氟氯西林联合用药、根据说明书推荐剂量用药有助于降低临床用药风险,CHPS 系统的应用对今后进行
大样本量真实世界用药评价具有重要意义。 |
| 关键词: 中国医院药物警戒系统 药物不良反应 头孢唑肟 儿童 |
| DOI：10.13407/j.cnki.jpp.1672-108X.2023.03.003 |
|
| 基金项目:广西壮族自治区卫生健康委员会自筹经费科研课题,编号Z20201130 |
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| Study on the Safety Evaluation of Ceftizoxime in Children Based on China Hospital Pharmacovigilance System |
| Nong Li, Mo Kai, Liang Ying’e, Qin Yan’e, Lan Xiaobu |
| (The First People’s Hospital of Nanning, Nanning 530022,China) |
| Abstract: |
| Objective: Drawing on the real-world data from the China Hospital Pharmacovigilance System (CHPS), to evaluate the
safety of ceftizoxime used in children of a hospital, and analyze the occurrence of ceftizoxime-related adverse drug reaction (ADR) and
its influencing factors. Methods: Based on the CHPS platform, single-center retrospective active monitoring was carried out on the
hospitalized children who had ceftizoxime for injection from February 2018 to April 2020. The system monitoring cases were evaluated by
double pharmacists, the incidence of ceftizoxime ADR was obtained, and its influencing factors were analyzed. Results: Totally 2,948
children who used ceftizoxime were monitored retrospectively, and 31 cases of ADR occurred, with an incidence of 1. 09%. Multivariate
logistic regression analysis showed that the combination of ceftizoxime and flucloxacillin and a single dose were independent influencing
factors of ADR in children using ceftizoxime. Conclusion: The incidence of ADR in children with ceftizoxime is not a rare range.
Reducing the combined use of flucloxacillin and adjusting the single dose according to the weight of the child will help reduce the clinical
risk of medication. The application of the CHPS platform is of great significance for future large-sample real-world medication evaluation. |
| Key words: China Hospital Pharmacovigilance System adverse drug reaction ceftizoxime children |
