| 摘要: |
| 目的:通过真实世界数据分析杭州地区青少年抑郁患者的用药现状,为临床治疗提供参考。 方法:收集杭州地区 12 家 医院 2018-2020 年青少年抑郁患者的用药数据,对患者基本资料、处方数据、用药方案等进行统计分析。 结果:杭州地区 2018- 2020 年青少年抑郁患者例次逐年上升,平均年龄逐年下降,女性例次高于男性;用药主要为一二线抗抑郁药、抗精神病药、镇静 催眠药等,其中舍曲林最常用;用药方案以二线抗抑郁药单用为主,一二线抗抑郁药与抗精神病药联用方案占比增长较快(年 复合增长率为 18. 66%);双相情感障碍组药物联用率较高(P<0. 05)。 结论:杭州地区青少年抑郁患者呈快速增长和年轻化趋 势,临床用药以二线治疗药物为主,并能根据患者实际症状遵循指南合理应用。 |
| 关键词: 青少年 抑郁症 抗抑郁药 用药分析 年复合增长率 双相情感障碍 |
| DOI：10.13407/j.cnki.jpp.1672-108X.2023.11.009 |
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| 基金项目: |
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| Medication Status of Adolescents with Depression in Hangzhou |
| Wu Fan1 , Tian Zitong2 |
| (1. The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006, China; 2. Shaanxi Provincial Cancer Hospital, Xi’an 710061, China) |
| Abstract: |
| To analyze the medication status of adolescents with depression in Hangzhou through real-world data, so as to provide reference for clinical treatment. Methods: Drug use data of adolescents with depression from 12 hospitals in Hangzhou from 2018 to 2020 were collected, and the basic information, prescription data and medication regimen of patients were statistically analyzed. Results: From 2018 to 2020, there was a year-on-year increase in the number of adolescent depression cases in Hangzhou. The average age of patients decreased over this period, and the number of female patients was larger than that of males. The most commonly prescribed medications included first- and second-line antidepressants, antipsychotic drugs, sedatives and hypnotics, with sertraline being the most frequently used. Predominant medication regimen was the use of second-line antidepressants as monotherapy. Drug combination of first- and second-line antidepressants with antipsychotic drugs showed significant increase in usage ( with a compound annual growth rate of 18. 66%). The rate of drug combination in bipolar affective disorder group was higher (P<0. 05). Conclusion: The number of adolescents with depression in Hangzhou is on the rise, with a trend towards younger patients. Clinical treatment primarily involves second-line medication, and treatment selections are aligned with patient symptoms and guidelines, indicating a rational approach to medication. |
| Key words: adolescents depression antidepressant analysis of drug use compound annual growth rate bipolar affective disorder |
