| 摘要: |
| 目的:评估 2%克立硼罗软膏治疗儿童轻中度特应性皮炎的疗效和安全性。 方法:84 例轻中度儿童特应性皮炎随机分为 治疗组 47 例和对照组 37 例,分别接受 2%克立硼罗软膏+润肤剂和单用润肤剂治疗,疗程为 4 周,比较两组患儿有效率和瘙痒 改善程度。 结果:治疗组和对照组的有效率分别为 72. 34%和 27. 03%,差异有统计学意义(P<0. 01)。 治疗组瘙痒评分较对照 组改善明显,尤以夜间瘙痒和动态瘙痒评分改善为主。 治疗组瘙痒改善率 63. 83%,明显高于对照组的 13. 51%。 药物不良反应 少见,仅为一过性局部刺激。 结论:2%克立硼罗软膏治疗儿童轻中度特应性皮炎安全有效。 |
| 关键词: 特应性皮炎 儿童 克立硼罗 疗效评价 安全性 |
| DOI：10.13407/j.cnki.jpp.1672-108X.2023.11.014 |
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| 基金项目: |
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| Efficacy of 2% Crisaborole Ointment in the Treatment of Mild to Moderate Atopic Dermatitis in Children |
| Pu Jie, Wu Wei, Li Zhijie, Ding Lan, Yang Ting |
| (Wuxi Children’s Hospital, Jiangsu Wuxi 214023, China) |
| Abstract: |
| Objective: To evaluate the efficacy and safety of 2% crisaborole ointment in the treatment of mild to moderate atopic dermatitis in children. Methods: A total of 84 children with mild to moderate atopic dermatitis were randomly divided into 47 cases in the treatment group and 37 cases in the control group, respectively treated with 2% crisaborole ointment+emollients and emollients alone for 4 weeks. The effective rate and degree of pruritus improvement in two groups were compared. Results: The effective rate of treatment group and control group were respectively 72. 34% and 27. 03%, with statistically significant difference (P<0. 01). The score of pruritus in the treatment group was significantly improved compared with the control group, with a particular predominance of improvement in nocturnal pruritus and dynamic pruritus score. The improvement rate of pruritus in the treatment group was 63. 83%, significantly higher than 13. 51% in the control group. Adverse drug reactions were rare, only transient local stimulation. Conclusion: 2% crisaborole ointment is safe and effective in the treatment of mild to moderate atopic dermatitis in children. |
| Key words: atopic dermatitis children crisaborole efficacy evaluation safety |
