| 摘要: |
| 目的:探讨新疆地区双相情感障碍患儿拉莫三嗪(LTG)血药浓度的影响因素,为临床个体化用药提供参考。 方法:采用超高效液相色谱法测定 LTG 血药浓度,分析年龄、性别、剂量及联合用药等对患儿 LTG 血药浓度的影响。 结果:150 例患儿服用LTG 后血药浓度为(4. 20±2. 57)μg / mL。 患儿年龄 11~18 岁,11 ~ <14 岁组和 14 ~ 18 岁组的给药剂量、血药浓度、浓度剂量比(CDR)比较差异均无统计学意义(P 均>0. 05);女性患儿的给药剂量、血药浓度和 CDR 均高于男性患儿(P 均<0. 05);维吾尔族和汉族患儿的给药剂量、血药浓度、CDR 比较差异均无统计学意义(P >0. 05);无联合用药组患儿的 LTG 给药剂量和血药浓度均高于 LTG+卡马西平组(P 均<0. 05)。 LTG 血药浓度与给药剂量呈正相关(P<0. 05),但相关性较差(r<0. 5)。 结论:临床使用 LTG 控制和治 |
| 关键词: 新疆 双相情感障碍 拉莫三嗪 血药浓度 |
| DOI：10. 13407/ j. cnki. jpp. 1672-108X. 2023. 09. 001 |
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| 基金项目:新疆维吾尔自治区自然科学基金项目,编号 2016D01C097 |
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| Influencing Factors of Blood Concentration of Lamotrigine in Children with Bipolar Disorder in Xinjiang |
| Zhao Ting, Zhang Huilan, Feng Jie, Wang Tingting, Sun Li, Yu Luhai, Li Hongjian |
| (People’ s Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, China) |
| Abstract: |
| Objective: To probe into the influencing factors of lamotrigine (LTG) blood concentration in children with bipolar disorder in Xinjiang, so as to provide reference for clinical individualized medication. Methods: The blood concentration of LTG was determined by ultra-high performance liquid chromatography, and the effects of age, gender, dose and drug combination on blood concentration of LTG in children were analyzed. Results: The blood concentration of 150 children after taking LTG was ( 4. 20± 2. 57) μg / mL. All children aged from 11 to 18 years, there were no statistically significant differences in the dose, blood concentration, and blood concentration and dose ratio (CDR) between the 11 to <14 year-old group and the 14 to 18 year-old group (P>0. 05). The dose, blood concentration and CDR of female children were higher than those of male children (P<0. 05). There were no statistically significant differences in the dose, blood concentration and CDR between Uighur and Han children (P>0. 05). The dose and blood concentration of LTG in the non-drug combination group were higher than those in LTG+carbamazepine group (P<0. 05). The blood concentration was positively correlated with dose of LTG administered (P<0. 05), but the correlation was poor (r<0. 5). Conclusion: Therapeutic drug monitoring (TDM) of LTG is necessary in the clinical use of LTG for the control and treatment of children with bipolar disorder so as to make timely dose adjustments for better control of bipolar episodes. |
| Key words: Xinjiang bipolar disorder lamotrigine blood concentration |
