| 摘要: |
| 目的:探讨临床药师基于治疗药物监测(TDM)指导儿童卡马西平中毒的药学监护。方法:临床药师参与1 例卡马西平
中毒患儿的治疗实践,利用卡马西平药代动力学特点,基于TDM 查阅文献,计算出患儿服用卡马西平的大致剂量,为临床救治
患儿提供参考,同时对患儿实施全程的药学监护。结果:患儿由昏迷转为清醒,通过连续性肾脏代替治疗,卡马西平血药浓度从
入院时62. 20 μg/ mL 降到出院时0. 12 μg/ mL,康复出院。结论:临床药师通过TDM 参与临床实践,利用药学知识协助临床救
治工作,并对患儿家属进行宣教,体现了临床药师的价值。 |
| 关键词: 卡马西平 治疗药物监测 中毒 药学监护 药代动力学 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2024.04.004 |
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| 基金项目: |
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| Pharmaceutical Care for a Child with Carbamazepine Poisoning Based on Therapeutic Drug Monitoring |
| Wu Jiale1,2, Yu Lingyan2, Dai Haibin2 |
| ((1. Qingyuan County People’s Hospital, Zhejiang Lishui 323800, China; 2. The Second
Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China)) |
| Abstract: |
| Objective: To probe into the pharmaceutical care for a child with carbamazepine poisoning based on therapeutic drug
monitoring (TDM) by clinical pharmacists. Methods: Clinical pharmacists participated into the treatment of a child with carbamazepine
poisoning. With the pharmacokinetic characteristics of carbamazepine, based on TDM and literature review, the approximate dose of
carbamazepine for children was calculated to provide reference for clinical treatment of children, meanwhile, the whole process of
pharmaceutical care for children was implemented. Results: The child was discharged out of danger, the blood concentration of
carbamazepine decreased from 62. 20 μg/ mL to 0. 12 μg/ mL through the continuous renal replacement therapy. Conclusion: Clinical
pharmacists participate into clinical practice through TDM, assist clinical treatment with pharmaceutical knowledge, and provide
education for the parents of the child, which reflects the value of clinical pharmacists |
| Key words: carbamazepine therapeutic drug monitoring poisoning pharmacokinetics |
