| 摘要: |
| 目的:分析双嘧达莫在儿童中的临床用药情况,为该药在儿童人群的合理应用及超说明书用药提供参考。方法:抽取广州
市妇女儿童医疗中心2016 年2 月22 日至2022 年5 月29 日使用双嘧达莫的18 岁以下患儿的病历资料,对患儿基本信息、疾病诊
断、用药时间和剂量等进行分析。结果:共抽出符合条件的患儿2 381 例,其中男1 567 例,女814 例。0~1 岁患儿250 例,>1~3 岁
患儿446 例,>3~12 岁患儿1 483 例。双嘧达莫在我院主要应用于肾脏疾病、消化道疾病、呼吸道疾病、心血管疾病和血液疾病
等。患儿用药时间多为30 天内,连续用药日剂量为12. 5~250. 0 mg,临时用药日剂量为3. 0~250. 0 mg,日剂量与患儿年龄呈正
相关,但相关性较弱。该院双嘧达莫超适应证用药部分有指南、文献或临床试验证据,超年龄用药有证据支持,且符合建议用
量。结论:双嘧达莫在儿科特定疾病的临床使用,未发现不良反应记录。 |
| 关键词: 双嘧达莫 儿童用药 临床数据分析 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2025.01.007 |
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| 基金项目: |
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| Clinical Application of Dipyridamole in Children in Our Hospital |
| Liu Yi, Tang Ying, Chen Zhanghua, Liu Ming, Mo Xiaolan, Zhang Yuxia |
| ((Guangzhou Women and Children’s Medical
Center, Guangzhou 510623, China)) |
| Abstract: |
| Objective: To analyze the clinical application of dipyridamole in children, so as to provide reference for rational application
and off-label use of dipyridamole in children. Methods: Medical records of patients under 18 years with dipyridamole from Feb. 22nd ,
2016 to May 29th , 2022 in Guangzhou Women and Children’s Medical Center were extracted. The basic information, disease diagnosis
and duration of medication dosage were analyzed. Results: A total of 2,381 medical records were extracted, including 1,567 males and
814 females. There were 250 children aged from 0 to 1 year, 446 children aged from 1 to 3 years, and 1,483 children aged from >3 to
12 years. The main diagnosis were renal diseases, gastrointestinal diseases, respiratory diseases, cardiovascular diseases and
hematological diseases. Patients were mostly administered within 30 d, with continuous daily doses ranging from 12. 5 to 250. 0 mg and
temporary daily doses ranging from 3. 0 to 250. 0 mg. Daily doses were positively correlated with patients’ age, yet the correlation was
weak. The off-label indication of dipyridamole at the hospital was partially supported by guidelines, literature or clinical trial evidence.
The off-label age was supported by evidence, and was consistent with the recommended dosage. Conclusion: No adverse drug reactions
have been documented for the clinical application of dipyridamole for specific diseases in pediatrics |
| Key words: dipyridamole pediatric drug use clinical data analysis |
