| 摘要: |
| 目的:探讨临床药师参与新生儿破伤风及撤药综合征的循证用药思路及监护要点。方法:临床药师参与1 例新生儿破
伤风及撤药综合征的药物治疗过程,对在家分娩的新生儿是否需预防破伤风和新生儿撤药综合征药物治疗进行证据检索。
结果:临床药师建议预防用1 500~3 000 U 破伤风抗毒素,并在确诊新生儿撤药综合征后给予苯巴比妥5 mg/ (kg·d) 维持治
疗。临床医师采纳用药建议,患儿惊厥控制后停用苯巴比妥。患儿生命体征平稳出院,出院后3 个月随访未再发生惊厥。
结论:临床药师在针对临床治疗经验少和治疗方案有争议的用药问题上,充分结合最佳证据给予临床治疗依据,在促进新生儿
临床安全、合理用药中发挥了一定作用。 |
| 关键词: 新生儿撤药综合征 破伤风 惊厥 药学实践 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2024.10.005 |
|
| 基金项目:武汉药学会医院药学学科发展项目,编号WHPA2022000007 |
|
| Evidence-Based Medication Practices of Clinical Pharmacists in the Prevention and Treatment of NeonatalTetanus and Drug Withdrawal Syndrome |
| Tang Jingyi, Xu Hao, Song Wenqi, Wang Na |
| ((Wuhan No. 1 Hospital, Wuhan 430022, China)) |
| Abstract: |
| Objective: To probe into the idea of evidence-based drug use and main points of monitoring of neonatal tetanus and drug
withdrawal syndrome with the participation of clinical pharmacists. Methods: Clinical pharmacists participated into the drug treatment of
a case of neonatal tetanus and drug withdrawal syndrome, and conducted evidence retrieval on whether neonates born at home need to
prevent tetanus and drug treatment of neonatal withdrawal syndrome. Results: Clinical pharmacists recommend prophylaxis with 1 500 to
3 000 U of tetanus antitoxin and maintenance therapy with phenobarbital 5 mg/ ( kg · d) after diagnosis of neonatal withdrawal
syndrome. Clinical recommendations were adopted and phenobarbital was discontinued after convulsive control. The infant was
discharged with stable vital signs, and no convulsion occurred at 3 months follow-up after discharge. Conclusion: Clinical pharmacists
have played a certain role in promoting the clinical safety and rational drug use of newborns by fully combining the best evidence to
provide clinical treatment basis for drug use problems with little clinical treatment experience and controversial treatment regimens |
| Key words: neonatal drug withdrawal syndrome tetanus seizure pharmaceutical practice |
