| 摘要: |
| 免疫球蛋白A 血管炎(immunoglobulin A vasculitis,IgAV)又称过敏性紫癜(Henoch-Schönlein purpura,HSP),多见于2~8 岁儿童,是儿童常见的免疫性疾病之一,主要临床表现为皮疹,可伴有消化道、关节、肾脏等多系统器官受累。IgAV 发病机制尚未完全阐明,目前认为感染、遗传易感性及免疫应答紊乱与IgAV 发病密切相关。其中免疫学异常主要包括体液免疫紊乱、细胞免疫失衡、炎症因子释放,有研究显示半乳糖缺陷型IgA1(Gd-IgA1)可能是IgAV 发病的主要原因之一。肠道作为最大免疫器官,含有数以万计的细菌及免疫细胞,肠道微生态平衡维护着免疫系统稳定,近年来发现肠道菌群相关免疫异常与免疫相关疾病关系密切,如炎症性肠病、肠易激综合征、过敏性疾病等 。笔者主要就IgAV肠道菌群失调相关免疫发病机制及治疗进展作一综述。 |
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| DOI：10.13407/j.cnki.jpp.1672-108X.2024.12.011 |
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| Progress of Correlation between Immunoglobulin A Vasculitis and Intestinal Flora |
| Li Pan, Wang Mo |
| (Children’s Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing 400014, China) |
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