| 摘要: |
| 目的:分析评价某妇幼保健院儿童住院患者静脉注射人免疫球蛋白(IVIG) 的使用情况,为临床合理使用IVIG 提供参
考。方法:抽取该院2022 年1 月-2023 年3 月儿科、新生儿科使用IVIG 住院患儿的病历142 份进行回顾性分析,统计患者的基
本信息、临床诊断、IVIG 剂量及疗程等资料,依据IVIG 药品说明书及国内外相关治疗指南,分析与评价IVIG 使用的合理性。结
果:142 例使用IVIG 的患儿中男70 例(49. 30%),女72 例(50. 70%),以新生儿为主(87 例,61. 27%),>28 d~1 岁患儿使用IVIG
的总量最大为290 g;使用人数最多的疾病为新生儿ABO 溶血,使用剂量最大的疾病为川崎病;IVIG 用药适应证符合其说明书
的39 例(27. 46%),适应证超说明书但符合指南推荐的82 例(57. 75%),说明书及指南均未提及或不推荐的21 例(14. 79%)。
结论:该院IVIG 临床使用存在没有得到指南推荐的超说明书用药现象,应进一步加强对IVIG 的用药监护,干预不合理用药情
况,促进IVIG 的临床合理应用。 |
| 关键词: 儿童 静脉注射人免疫球蛋白 适应证 合理用药 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2025.07.011 |
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| 基金项目:湖南创新型省份建设专项,编号2023SK4083;长沙市中医药科研课题,编号SB2024-077。 |
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| Evaluation on Application and Rationality of Intravenous Immunoglobulin in a Grade Ⅲ, Level AMaternal and Child Health Care Hospital |
| Liu Xiaojuan, Pan Xia, Liu Shasha, Gong Xiaohui, Chen Na |
| ((Changsha Hospital for Maternal & Child Care Affiliated to
Hunan Normal University, Changsha 410007, China)) |
| Abstract: |
| Objective: To analyze and evaluate the application of intravenous immunoglobulin (IVIG) for children hospitalized at a
maternal and child health care hospital, so as to provide reference for the rational application of IVIG in clinical practice. Methods:
Retrospective analysis was performed on 142 hospitalized children with IVIG from Pediatrics and Neonatology from Jan. 2022 to Mar.
2023. Based on the drug instructions and clinical application guidelines at home and abroad, the application rationality of IVIG was
analyzed from basic information, clinical diagnosis, dosage of IVIG, and treatment course. Results: Among the 142 children who
received IVIG, 70 cases were male (49. 30%) and 72 cases were female (50. 70%). The majority were newborns (87 cases,
61. 27%). For children aged >28 d to 1 year, the maximum amount of IVIG used was 290 g. The disease with the largest number of
cases was neonatal ABO hemolysis, and the disease with the highest dosage used was Kawasaki disease. There were 39 cases (27. 46%)
with indications of IVIG according to the drug instructions, 82 cases (57. 75%) with off-label indications according to the drug
instructions but in accordance with the guidelines, and 21 cases (14. 79%) with indications not mentioned in the drug instructions or not
recommended by the guidelines. Conclusion: There are some phenomenon of off-label application of IVIG in our hospital, which is not
recommended by the guidelines. It is necessary to further strengthen the monitoring of IVIG, intervene the irrational application of drugs,
and promote the rational clinical application of IVIG. |
| Key words: children intravenous immunoglobulin indications rational medication |
