| 摘要: |
| 目的:探讨危重症新生儿万古霉素谷浓度监测达标率低的影响因素。 方法:纳入 2018 年 12 月至 2023 年 12 月在西北妇 女儿童医院接受万古霉素治疗的新生儿,接受静脉滴注万古霉素治疗的年龄≤28 d,胎龄≥26 周妊娠出生的新生儿。 分析万古 霉素给药方案,监测稳态万古霉素谷浓度。 结果:共纳入 146 例患儿,15. 06%(22 / 146)的患儿万古霉素谷浓度<5 mg / L。 单因 素回归分析结果显示,胎龄、体质量、身高、万古霉素日剂量与万古霉素谷浓度显著相关(P<0. 05)。 多元线性回归分析显示,胎 龄、体质量、万古霉素日剂量是万古霉素谷浓度低的独立影响因素(P<0. 05)。 结论:新生儿万古霉素谷浓度监测达标率低,尤 其是重症新生儿,万古霉素日剂量、胎龄、体质量是重要的影响因素。 |
| 关键词: 万古霉素 谷浓度 影响因素 新生儿 |
| DOI：10.13407/j.cnki.jpp.1672-108X.2025.03.010 |
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| 基金项目:西安市创新能力支撑计划,编号 23YXYJ0143。 |
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| Monitoring of Trough Concentration of Vancomycin in 146 Neonates and Analysis of Its Influencing Factors: a Single Center, Retrospective Observational Study |
| Chen Hui, Liu Zhenguo, Ju Kanglu, Chang Ying, Guo Bo |
| (Northwest Women’s and Children’s Hospital, Xi’an 710061, China) |
| Abstract: |
| Objective: To probe into the influencing factors of low compliance rate of vancomycin trough concentration monitoring in critically ill neonates. Methods: Neonates with vancomycin treatment admitted into the Northwest Women’ s and Children’ s Hospital from Dec. 2018 to Dec. 2023, aged ≤28 d treated with intravenous vancomycin, and with gestational age ≥26 weeks were enrolled. Results: A total of 146 patients were included, and 15. 06% (22 / 146) of patients had a trough concentration of vancomycin <5 mg / L. Univariate regression analysis showed that gestational age, body weight, height, vancomycin daily dose were significantly correlated with trough concentration of vancomycin ( P < 0. 05). Multiple linear regression analysis showed that gestational age, body weight, and vancomycin daily dose were independent influencing factors for low trough concentration of vancomycin (P<0. 05). Conclusion: The daily dose, gestational age and body weight of vancomycin are the important influencing factors affecting the compliance rate of trough concentration of vancomycin monitoring in neonates, especially in severe neonates. |
| Key words: vancomycin trough concentration influencing factors neonates |
