| 摘要: |
| 目的:探讨肾病综合征合并嗜酸性粒细胞增多症的病因、临床特征及转归。方法:回顾性分析1 例肾病综合征合并重度
嗜酸性粒细胞增多症患儿的临床资料,并进行文献复习。结果:患儿,男,6 岁,2020 年诊断为肾病综合征,2023 年11 月出现肛
门及包皮处瘙痒,入院后完善相关检查,血常规示嗜酸性粒细胞计数36. 09×109 / L,骨髓涂片示嗜酸性粒细胞百分比50%,
PDGFRA、PDGFRB、FGFR1 等基因检测阴性,诊断为重度嗜酸性粒细胞增多、药物超敏综合征,给予醋酸泼尼松治疗后病情好
转。结论:儿童肾病综合征伴重度嗜酸性粒细胞增多症是一种罕见的临床综合征,病因复杂,需积极找寻病因,警惕药物所致不
良反应,关注长期随访。 |
| 关键词: 嗜酸性粒细胞增多症 肾病综合征 儿童 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2025.07.009 |
|
| 基金项目:东部战区总医院临床研究专项续航项目,编号22LCYYXH9、22LCYYQH9 |
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| Nephrotic Syndrome Complicated with Severe Eosinophilia: a Case Report and Literature Review |
| Ma Chenxi, Kuang Qianhuining, Liu Jiuyu, Zhang Pei, Xia Zhengkun, Gao Chunlin |
| ((Jinling School of Clinical
Medicine, Nanjing Medical University, Nanjing 210002, China)) |
| Abstract: |
| Objective: To probe into the etiology, clinical characteristics, and outcomes of nephrotic syndrome complicated with
eosinophilia. Methods: Retrospective analysis was performed on clinical data of a child with nephrotic syndrome complicated with severe
eosinophilia, and relevant literature were reviewed. Results: A 6-year-old boy had been diagnosed with nephrotic syndrome in 2020 and
developed anal and prepuce itching in Nov. 2023. Upon admission, laboratory tests revealed a peripheral blood eosinophil count of
36. 09×109 / L, and bone marrow aspiration showed eosinophils accounting for 50% of nucleated cells. Genetic testing for PDGFRA,
PDGFRB, and FGFR1 mutations was negative. The child was diagnosed with severe eosinophilia and drug hypersensitivity syndrome.
Treatment with prednisone acetate led to significant clinical improvement. Conclusion: Nephrotic syndrome complicated with severe
eosinophilia in children is a rare clinical syndrome with complex etiologies. It is crucial to identify the underlying causes, vigilant for
potential drug-related adverse drug reactions, and monitor long-term follow-up. |
| Key words: eosinophilia nephrotic syndrome children |
