| 摘要: |
| 目的:探讨菖麻熄风片联合阿立哌唑治疗小儿多发性抽动症的临床疗效及对血清胰岛素样生长因子-1(IGF-1)、去甲肾
上腺素(NE)水平的影响。方法:选取我院2022 年4 月至2024 年5 月收治的124 例多发性抽动症患儿按随机数表法分为对照
组和观察组各62 例,对照组给予阿立哌唑治疗,观察组在对照组治疗基础上联合菖麻熄风片治疗。结果:治疗后,观察组治疗
临床总有效率为91. 94%,明显高于对照组的77. 42%(P<0. 05)。治疗后,两组患儿耶鲁抽动症整体严重程度量表评分、NE、多
巴胺水平均显著下降,青少年心理健康量表评分、γ-氨基丁酸、IGF-1 水平均明显上升,且观察组优于对照组(P<0. 05)。结论:
菖麻熄风片联合阿立哌唑治疗小儿多发性抽动症在缓解抽动程度、调节神经递质、提升IGF-1 水平等方面优于单独使用阿立哌
唑治疗,综合疗效显著,安全性较高。 |
| 关键词: 多发性抽动症 儿童 菖麻熄风片 阿立哌唑 去甲肾上腺素 胰岛素样生长因子-1 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2025.08.004 |
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| 基金项目: |
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| Clinical Efficacy of Changma Xifeng Tablets Combined with Aripiprazole in the Treatment of Children withMultiple Tic Disorders |
| Lei Xiao, Wu Guolian, Bi Genwang, Jia Lan, Wang Zhen |
| (Cangzhou People’s Hospital, Hebei Cangzhou 061000, China) |
| Abstract: |
| Objective: To probe into the clinical efficacy of Changma Xifeng tablets combined with aripiprazole in the treatment of
multiple tic disorders in children and its effects on the levels of serum insulin-like growth factor-1 (IGF-1) and norepinephrine (NE).
Methods: A total of 124 children with multiple tic disorders admitted into our hospital from Apr. 2022 to May 2024 were randomly
divided into the control group and observation group according to the random number table method, with 62 cases in each group. The
control group was treated with aripiprazole, while the observation group received Changma Xifeng tablets based on the control group.
Results: After treatment, the total clinical effective rate of the observation group was 91. 94%, significantly higher than 77. 42% of the
control group (P<0. 05). After treatment, the Yale Tourette Syndrome Global Severity Scale, NE and dopamine levels in both groups
decreased significantly, while the Adolescent Mental Health Scale, γ-aminobutyric acid and IGF-1 increased significantly, the
observation group was superior to the control group (P<0. 05). Conclusion: Changma Xifeng tablets combined with aripiprazole in the
treatment of children with multiple tic disorders is superior to aripiprazole alone in relieving tic intensity, regulating neurotransmitters,
and enhancing IGF-1. The comprehensive efficacy is significant and the safety is relatively high. |
| Key words: multiple tic disorders children Changma Xifeng tablets aripiprazole norepinephrine insulin-like growth factor-1 |
