| 摘要: |
| 目的:分析1 例聚多卡醇致儿童面部皮肤肿胀坏死不良反应,并复习相关不良反应文献,总结聚多卡醇不良反应的发生
特点、影响因素及防治要点,为临床安全合理使用聚多卡醇提供参考。方法:报道1 例因面部血管畸形接受聚多卡醇治疗后出
现面部皮肤肿胀坏死患儿的临床资料,以“聚多卡醇” “不良反应” 等作为关键词,全面检索国内外权威数据库如中国知网、万
方、PubMed 等自建库起至2025 年3 月1 日的相关文献报道进行文献复习。结果:本例患儿在用药后出现面部皮肤肿胀,并进
展为坏死。文献复习发现,聚多卡醇导致儿童不良反应多样,除皮肤肿胀坏死外,对神经系统、心血管系统、呼吸系统等都可能
有影响。不良反应发生与给药途径、用药剂量及医师操作手法紧密相关。结论:临床应用聚多卡醇时,需严格掌握适应证,精准
控制用药剂量与给药途径,密切监测用药后反应。一旦发生不良反应,应及时采取有效干预措施,以降低严重不良反应发生率,
保障患儿用药安全。 |
| 关键词: 硬化治疗 聚多卡醇 肿胀坏死 |
| DOI：10.13407/j.cnki.jpp.1672-108X.2025.06.013 |
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| 基金项目: |
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| Kunming Children’s Hospital, Kunming 650228,China |
| Zong Jing, Li Shuang, Yan Aihua, Xie Qibing, Pu Ming, Li Huiying |
| (Kunming Children’s Hospital, Kunming 650228,China) |
| Abstract: |
| Objective: To analyze the adverse drug reaction of facial skin swelling and necrosis induced by polydocanol in a child, and
to summarize the occurrence characteristics, influencing factors, prevention and treatment points of polydocanol-induced adverse drug
reaction by reviewing the related literature, so as to provide reference for the safe and rational use of polydocanol in clinic. Methods:
Clinical data of a child with facial skin swelling and necrosis after receiving treatment with polidocanol due to facial vascular malformation
were reported. Taking “polykadol” “adverse drug reactions” as key words, comprehensive literature review was performed by retrieving
relevant literature from authoritative databases at home and abroad such as CNKI, Wanfang, PubMed from the database establishment to
Mar. 1st , 2025. Results: The child developed facial skin swelling and progressed to necrosis after medication. Literature review
indicated that polidocanol could cause various adverse drug reactions in children, in addition to skin swelling and necrosis, polydocanol
may affect the nervous system, cardiovascular system and respiratory system. The occurrence of adverse drug reaction was closely related
to the route of administration, the dosage of medication and the operation techniques of clinicians. Conclusion: When using polidocanol
for clinical treatment, it is necessary to strictly control the indications, accurately control the dosage and route of administration, and
closely monitor the reactions after medication. In case of adverse drug reactions, effective intervention measures should be taken in time
to reduce the incidence of severe adverse drug reactions and ensure the medication safety in children. |
| Key words: sclerotherapy polidocanol swelling and necrosis |
