| 摘要: |
| 目的:探讨新生儿呼吸窘迫综合征(NRDS) 患儿血清穿透素-3( PTX-3) 表达水平及其与疾病严重程度和预后的关系。
方法:回顾性选取我院符合纳入标准的160 例NRDS 患儿为研究对象,根据预后分为生存组和死亡组。采用新生儿急性生理学
评分围产期补充Ⅱ(SNAPPE-Ⅱ)评估患儿危重程度,酶联免疫吸附试验(ELISA)法检测PTX-3、白细胞介素(IL)-6、肿瘤坏死因
子-α(TNF-α)、IL-1β 水平。采用logistic 回归分析NRDS 患儿死亡的影响因素。结果:死亡组血清PTX-3、TNF-α、IL-6 水平及
SNAPPE-Ⅱ评分高于生存组( P <0. 05)。血清PTX-3 水平、SNAPPE-Ⅱ评分单独及联合预测NRDS 患儿死亡的曲线下面积
(AUC)分别为0. 846、0. 830、0. 902。PTX-3 水平、SNAPPE-Ⅱ评分与NRDS 患儿死亡有关(P<0. 05)。结论:PTX-3 水平与NRDS
患儿疾病严重程度、预后均有关,可能成为NRDS 潜在评估指标。 |
| 关键词: 新生儿呼吸窘迫综合征 穿透素-3 预后 新生儿急性生理学评分围产期补充Ⅱ |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2025.11.002 |
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| 基金项目: |
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| Evaluation Value of Penetrin-3 on Prognosis of Neonatal Respiratory Distress Syndrome |
| Yuan Lijun, Jiang Gangjian, Zhang Haixia, Xie Qiaotao, Guo Xiaoyan |
| (Luohe Central Hospital / Luohe Medical College First
Affiliated Hospital, Henan Luohe 462000, China) |
| Abstract: |
| Objective: To probe into the expression level of serum pentraxin-3 (PTX-3) in neonatal respiratory distress syndrome
(NRDS) and its correlation with the severity and prognosis of the disease. Methods: Totally 160 children with NRDS who met the
inclusion criteria in our hospital were retrospectively extracted to be divided into the survival group and death group according to the
prognosis. The critical degree of patients was evaluated by the Score for Neonatal Acute Physiology with Perinatal Extension-Ⅱ
(SNAPPE-Ⅱ). The levels of PTX-3, interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and IL-1β were detected by enzymelinked
immunosorbent assay (ELISA). Logistic regression analysis was used to identify the factors influencing the mortality of children
with NRDS. Results: The serum levels of PTX-3, TNF-α, IL-6 and SNAPPE-Ⅱ in the death group were higher than those in the
survival group (P<0. 05). The area under the curve (AUC) of serum PTX-3 level, SNAPPE-Ⅱ and the combination predicting death
in children with NRDS was 0. 846, 0. 830 and 0. 902, respectively. PTX-3 and SNAPPE-Ⅱ were associated with mortality in children
with NRDS (P < 0. 05). Conclusion: PTX-3 is related to the severity and prognosis of NRDS, and may potentially serve as an
assessment indicator of NRDS. |
| Key words: neonatal respiratory distress syndrome penetrin-3 prognosis Score for Neonatal Acute Physiology with Perinatal
Extension-Ⅱ |
