| 摘要: |
| 目的:报道1 例米诺环素致儿童牙齿黄染的案例并进行文献探讨,为国内外儿童患者使用米诺环素提供相关警示和参
考。方法:分析1 例肺炎支原体肺炎(大环内酯类耐药) 感染的患儿使用米诺环素胶囊后,出现不良反应的特点,结合相关文
献,对其剂量与疗程、变色特征、发生机制及防治措施进行探讨。结果:经双重关联性分析,患儿的牙齿黄染很可能为米诺环素
胶囊所致。结论:儿童使用四环素引起发育期的牙齿变色已被证实,但使用米诺环素的危害尚未得到重视。8 岁以上儿童使用
米诺环素虽然不属于超说明书用药,但也应对其安全性和潜在风险进行充分评估,并做好药学监护。 |
| 关键词: 米诺环素 不良反应 牙齿黄染 儿童 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2026.05.013 |
|
| 基金项目:基金项目:中国药学会医院药学专业委员会医院药学科研专项资助项目,编号CPA-Z05-ZC-2021-002;中国医药教育协会《医院高质量发展
与药学创新研究》专项课题,编号2024-PJZXKT-07。 |
|
| Dental Discoloration Induced by Minocycline Treatment for Mycoplasma Pneumoniae Pneumonia: a CaseReport and Literature Review |
| Shi Yi1,2, Li Yijun2, Zhu Yan2, Zeng Na2, Hu Wenjuan2 |
| (1. The Affiliated Suzhou Hospital of Nanjing University Medical
School, Jiangsu Suzhou 215153, China. 2. Shanghai Children’ s Hospital, School of Medicine, Shanghai Jiao Tong University,
Shanghai 200040, China) |
| Abstract: |
| Objective: To explore a case of minocycline-induced dental discoloration, and to provide relevant warnings and references
for the use of minocycline in children at home and abroad. Methods: A case of Mycoplasma pneumoniae pneumonia (macrolideresistant)
infection in a child was treated with minocycline capsules, and the characteristics of adverse drug reactions were analyzed.
Based on relevant literature, the dosage and treatment duration, discoloration characteristics, occurrence mechanism and prevention
measures were discussed. Results: Based on a dual-correlation analysis, dental discoloration of the child was highly induced by
minocycline capsules. Conclusion: It has been confirmed that tetracycline in children can cause discoloration of teeth during the
developmental stage, but the risks associated with minocycline have not yet received adequate attention. Although the use of minocycline
in children >8 years does not constitute off-label use, its safety and potential risks should be thoroughly evaluated, and appropriate
pharmaceutical monitoring should be implemented. |
| Key words: minocycline adverse drug reactions dental discoloration children |
