| 摘要: |
| 目的:探讨支气管肺炎患儿血清β 防御素2(HBD2)、热休克蛋白70(HSP70)、C 反应蛋白(CRP)表达与病情严重程度和
疾病转归的关系。方法:选取2022 年1 月至2024 年5 月三亚市中医院收治的138 例支气管肺炎患儿为支气管肺炎组,根据病
情严重程度将其分为轻度组和重度组。另选同期我院138 例体检健康儿童为对照组。根据支气管肺炎患儿临床转归情况分为
转归良好组和转归不良组。采用酶联免疫吸附试验(ELISA) 法检测血清HBD2、HSP70 水平,免疫比浊法检测血清CRP 水平,
logistic 多因素回归分析患儿疾病转归影响因素,受试者工作特征(ROC)曲线分析患儿疾病转归的预测价值。结果:支气管肺炎
组患儿血清HBD2、HSP70、CRP 水平高于对照组(P<0. 05);重度组血清HBD2、HSP70、CRP 水平高于轻度组(P<0. 05)。转归
良好组和转归不良组患儿在是否早产,户外活动时间,血清HBD2、HSP70、CRP 水平方面的比较差异有统计学意义(P<0. 05)。
血清HBD2、HSP70、CRP 水平,早产,户外活动时间<2 h 是支气管肺炎患儿疾病转归的危险因素(P<0. 05)。ROC 曲线显示,血
清HBD2、HSP70、CRP 三者联合预测支气管肺炎患儿疾病转归的曲线下面积(AUC) 高于HBD2、HSP70、CRP 单独预测的AUC
(Z =3. 842、4. 568、4. 404,P 均<0. 01)。结论:支气管肺炎患儿血清HBD2、HSP70、CRP 水平升高,与疾病严重程度有关,且三者
联合检测对支气管肺炎患儿疾病转归具有较高的预测价值。 |
| 关键词: 支气管肺炎 β 防御素2 热休克蛋白70 C 反应蛋白 疾病转归 |
| DOI：10.13407/j.cnki.jpp.1672-108X.2025.12.006 |
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| 基金项目: |
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| Establishment of Disease Outcome Assessment Model and Prevention Strategies Based on Serum β-Defensin-2,Heat Shock Protein 70, and C-Reactive Protein Expression Levels in Children with Bronchopneumonia |
| Wu Nianjie, Huang Zheng, Chen Liling, Wang Suli |
| (Sanya Hospital of Traditional Chinese Medicine, Hainan Sanya
572000, China) |
| Abstract: |
| Objective: To probe into the correlation between serum β-defensin-2 (HBD2), heat shock protein 70 (HSP70), and
C-reactive protein (CRP) expression levels in children with bronchopneumonia and the disease severity and outcome. Methods: From
Jan. 2022 to May 2024, totally 138 children with bronchopneumonia admitted into Sanya Hospital of Traditional Chinese Medicine were
enrolled as the bronchopneumonia group. According to the disease severity, all patients were divided into the mild group and severe
group. Another 138 healthy children who underwent physical examinations at our hospital were enrolled as the control group. According
to the clinical outcome of children with bronchopneumonia, all patients were divided into the good outcome group and poor outcome
group. Enzyme linked immunosorbent assay (ELISA) was applied to detect serum HBD2 and HSP70 levels, and immunoturbidimetry
was used to detect serum CRP levels. And logistic multiple regression was applied to analyze the influencing factors of disease outcome
in children. The predictive value for disease outcome of children was analyzed by receiver operating characteristic (ROC) curve.
Results: The serum HBD2, HSP70, and CRP levels in bronchopneumonia group were higher than those in control group (P<0. 05).
The serum HBD2, HSP70, and CRP levels in severe group were higher than those in mild group (P<0. 05). There was statistically
significant difference in premature birth, outdoor activity time and serum HBD2, HSP70, CRP levels between good outcome group and
poor outcome group (P<0. 05). Serum HBD2, HSP70, CRP levels, premature birth and outdoor activity time <2 h were risk factors for
disease outcome in children with bronchopneumonia (P<0. 05). ROC curve results showed that the area under the curve (AUC) of
combined prediction of serum HBD2, HSP70, CRP levels for disease outcome in children with bronchopneumonia was higher than that of
HBD2, HSP70, and CRP alone (Z =3. 842, 4. 568, and 4. 404, all P<0. 01). Conclusion: The elevated serum HBD2, HSP70, and
CRP levels in children with bronchopneumonia are related to disease severity, and the combination of serum HBD2, HSP70, CRP levels
has high predictive value for disease outcome in children with bronchopneumonia. |
| Key words: bronchopneumonia human β-defensin 2 heat shock protein 70 C-reactive protein disease outcome |
