| 摘要: |
| 目的:探讨小续命汤化裁方辅助西医治疗儿童重症脑炎的疗效及体感诱发电位分析。方法:选取2023 年1 月至2025 年1 月郑州大学附属儿童医院90 例重症脑炎患儿,根据不同治疗方案分组,将使用阿昔洛韦、丙种球蛋白治疗的45 例纳入对照组,使用小续命汤化裁方联合阿昔洛韦、丙种球蛋白治疗的45 例纳入研究组。比较两组患儿治疗效果、中医证候积分、辅助性T 细胞17(Th17) / 调节性T 细胞(Treg)相关细胞因子、体感诱发电位及不良反应等。结果:治疗2 周后,研究组总有效率高于对照组(P<0. 05)。治疗2 周后,研究组嗜睡昏蒙、四肢厥冷、面色苍白、喉中痰鸣、肢体困重评分均低于对照组,血清白细胞介素(IL)-10、转化生长因子-β1(TGF-β1)水平高于对照组,IL-17、IL-6 水平低于对照组,体感诱发电位分级改善情况优于对照组(P<0. 05)。两组患儿不良反应总发生率比较差异无统计学意义(P>0. 05)。结论:小续命汤化裁方辅助西医治疗儿童重症脑炎效果确切,可有效缓解中医证候,减轻炎症反应,改善体感诱发电位。 |
| 关键词: 脑炎 小续命汤 诱发电位 疗效 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2026.04.013 |
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| 基金项目: |
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| Clinical Efficacy of Modified Xiaoxuming Decoction Assisted with Western Medicine in the Treatment of Severe Encephalitis in Children and Analysis of Somatosensory Evoked Potentials |
| Song Yinqiao, Li Qianqian, Xue Yingjie |
| (Children’s Hospital Affiliated to Zhengzhou University, Henan Children’s Hospital, Zhengzhou Children’s Hospital, Zhengzhou 450018, China) |
| Abstract: |
| Objective: To probe into the clinical efficacy of modified Xiaoxuming decoction assisted with Western medicine in the treatment of severe encephalitis in children and analyze the somatosensory evoked potentials. Methods: A total of 90 children with severe encephalitis were extracted from Children’s Hospital Affiliated to Zhengzhou University from Jan. 2023 to Jan. 2025. According to different treatment regimens, 45 patients treated with acyclovir and gamma globulin were included in the control group, and 45 patients treated with modified Xiaoxuming decoction assisted with gamma globulin and acyclovir were included in the research group. The therapeutic effects, traditional Chinese medicine syndrome scores, helper T cell 17 (Th17) / regulatory T cell (Treg) related cytokines, and somatosensory evoked potentials and adverse drug reactions of two groups were compared. Results: After 2 weeks of treatment, the total effective rate of research group was higher than that of control group (P<0. 05). After 2 weeks of treatment, the scores of lethargy, cold limbs, pale complexion, sputum in the throat and limb distress in research group were lower than those in control group, the levels of serum interleukin (IL)-10 and transforming growth factor-β1 (TGF-β1) were higher than those in control group, the levels of IL-17 and IL-6 were lower than those in control group, and the improvement of somatosensory evoked potential grading was
better than that in control group (P<0. 05). There was no statistically significant difference in the total incidence of adverse adverse
reactions between two groups (P>0. 05). Conclusion: Modified Xiaoxuming decoction assisted with western medicine is effective in the
treatment of severe encephalitis in children, which can effectively alleviate traditional Chinese medicine syndromes, reduce inflammatory
response and improve somatosensory evoked potentials. |
| Key words: encephalitis Xiaoxuming decoction evoked potentials efficacy |
