| 摘要: |
| 目的:分析临床药师参与治疗苯唑西林导致骨髓炎患儿出现严重中性粒细胞缺乏伴发热的药学实践。 方法:对 1 例苯 唑西林导致骨髓炎患儿出现严重中性粒细胞缺乏伴发热的临床资料进行回顾性分析,及时停用可疑药物,调整为头孢羟氨苄口 服抗感染治疗,并给予粒细胞刺激因子和布洛芬等对症治疗。 结果:停用苯唑西林及对症处理 3 天后患儿中性粒细胞及体温恢 复正常。 出院 2 周后随访患儿情况良好。 结论:对于骨关节感染患儿使用苯唑西林应做好药学监护,定期监测血细胞,出现中 性粒细胞减少的患儿需及时停药并积极采用对症处理措施 |
| 关键词: 苯唑西林 骨髓炎 中性粒细胞缺乏 发热 |
| DOI：10.13407/j.cnki.jpp.1672-108X.2026.03.011 |
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| 基金项目:2024 年河南省科技攻关计划,编号 242102310104。 |
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| Pharmaceutical Care for a Child with Osteomyelitis and Severe Neutropenia with Fever Induced by Oxacillin |
| Yan Congcong, Guo Zhanhao, Liu Fangna, Lyu Meng, Zhang Shengnan |
| (Children’ s Hospital Affiliated to Zhengzhou University, Zhengzhou 450018, China) |
| Abstract: |
| Objective: To analyze the pharmaceutical care of clinical pharmacists for a child with osteomyelitis and severe neutropenia with fever induced by oxacillin. Methods: Retrospective analysis was performed on a child with osteomyelitis who developed severe neutropenia with fever induced by oxacillin. The suspected drug was promptly discontinued, and the anti-infective therapy was switched to oral cefadroxil. Symptomatic treatment, including granulocyte colony-stimulating factor and ibuprofen, was administered. Results: Three days after discontinuing oxacillin and symptomatic treatment, the level of neutrophil and body temperature of the child returned to the normal state. Two weeks after discharge, the child was followed up and found to be in good condition. Conclusion: Pharmacovigilance is essential during oxacillin therapy for children with bone and joint infections, including regular monitoring of blood cell counts. Immediate drug withdrawal and active symptomatic intervention are warranted if neutropenia occurs. |
| Key words: oxacillin osteomyelitis neutropenia fever |
