| 摘要: |
| 目的:探讨他克莫司致儿童不良反应的特点,为儿科临床合理用药提供参考。方法:检索中国知网、万方和PubMed 数据
库,时限为2018 年1 月-2024 年8 月,收集他克莫司在儿童群体中的不良反应的案例并对患儿一般疾病情况、不良反应发生类
型和转归等指标进行汇总分析。结果:经过筛选共纳入文献21 篇(中文文献12 篇,英文文献9 篇),包括23 例病例;累及的系
统/ 器官有神经系统(11 例,47. 82%)、血液系统(4 例,17. 39%)、消化系统(4 例,17. 39%)、内分泌系统(2 例,8. 70%)、泌尿系统
(1 例,4. 35%)、呼吸系统(1 例,4. 35%)。严重的不良反应有躁狂症、肝窦阻塞综合征、巴特综合征等。结论:他克莫司在儿童患者
中的常见不良反应与药品说明书具有一致性,大部分不良反应出现在用药后3 个月内,必要时需监测血药浓度。 |
| 关键词: 他克莫司 儿童 病例分析 不良反应 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2026.10.015 |
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| 基金项目: |
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| Literature Analysis of Adverse Drug Reactions Induced by Tacrolimus in Children |
| Ma Mingjian |
| ((Department of Pharmacy, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for
Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child
Rare Diseases in Infection and Immunity, Chongqing 400014, China)) |
| Abstract: |
| Objective: To explore the characteristics of adverse drug reactions induced by tacrolimus in children, and provide reference
for rational drug use in pediatric clinical practice. Methods: CNKI, Wanfang and PubMed databases were retrieved to collect case
reports on adverse drug reactions induced by tacrolimus in children from Jan. 2018 to Aug. 2024, statistical analysis was performed on
indicators such as general disease conditions, systems of adverse drug reactions onset, and outcome. Results: After screening, a total of
21 articles were enrolled (12 in Chinese and 9 in English), including 23 cases. The systems/ organs involved were nervous system
(11 cases, 47. 82%), blood system (4 cases, 17. 39%), digestive system (4 cases, 17. 39%), endocrine system (2 cases, 8. 70%),
urinary system (1 case, 4. 35%), and respiratory system (1 case, 4. 35%). Severe adverse drug reactions included mania, sinusoidal
obstruction syndrome and Bartter-like syndrome. Conclusion: The common adverse drug reactions of tacrolimus are consistent with the
drug instructions in pediatric patients. Most of the adverse drug reactions occur within 3 months, and the blood concentration should be
monitored if necessary. |
| Key words: tacrolimus children case analysis adverse drug reactions |
