| 摘要: |
| 目的:探究产前地塞米松暴露对子代注意缺陷多动障碍(ADHD)的影响。 方法:选取我院 2022 年 10 月至 2024 年 4 月收 治的以注意力不集中或多动为主诉的疑似 ADHD 患儿 102 例,确诊 ADHD 患儿 86 例,根据产前有无使用地塞米松分为地塞米 松暴露组 20 例和非地塞米松暴露组 66 例。 采用 SNAP-Ⅳ和 Weiss’s 功能性缺陷程度量表评估患儿的状态;检测患儿的营养水 平。 结果:地塞米松暴露组 SNAP-Ⅳ评分和 Weiss’s 功能性缺陷程度评分均显著高于非地塞米松暴露组(P<0. 05)。 地塞米松 暴露组血清 25 羟基维生素 D[25(OH)D]、铜(Cu)、锌(Zn)均低于非地塞米松暴露组(P<0. 05),铅(Pb)高于非地塞米松暴露 组(P<0. 05)。 结论:产前地塞米松暴露与患儿 ADHD 的发生以及营养水平有关。 |
| 关键词: 地塞米松 注意缺陷多动障碍 子代 |
| DOI：10.13407/j.cnki.jpp.1672-108X.2026.03.009 |
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| 基金项目: |
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| Clinical Analysis of Prenatal Exposure of Dexamethasone on Attention Deficit Hyperactivity Disorder in Offspring |
| Miao Lingling, Wang Zhengjun, Zhu Xiaobo, Kang Yunfeng, Chen Yuxiang |
| (Rugao People’s Hospital, Jiangsu Nantong 226500, China) |
| Abstract: |
| Objective: To probe into the effects of prenatal exposure to dexamethasone on attention deficit hyperactivity disorder (ADHD) in offspring. Methods: From Oct. 2022 to Apr. 2024, totally 102 children with suspected ADHD who complained of inattention or hyperactivity were extracted from our hospital, with 86 children confirmed of ADHD. According to the application of dexamethasone before delivery, the patients were divided into the dexamethasone exposure group (20 cases) and the non-dexamethasone exposure group (66 cases). The SNAP-Ⅳ score and Weiss’s functional defect severity score were used to evaluate the status and detect the nutritional level of children. Results: The SNAP-Ⅳ score and Weiss’ s functional defect severity score in the dexamethasone exposure group were obviously higher than those in the non-dexamethasone exposure group ( P < 0. 05). the serum levels of 25 hydroxyvitamin D [25(OH)D], copper (Cu), and zinc (Zn) in the dexamethasone exposure group were significantly lower than those in the non-dexamethasone exposure group ( P < 0. 05), and lead ( Pb) was significantly higher than that in the non-dexamethasone exposure group (P<0. 05). Conclusion: Prenatal exposure to dexamethasone is associated with the occurrence of ADHD and nutritional level in children. |
| Key words: dexamethasone attention deficit hyperactivity disorder offspring |
