| 摘要: |
| 目的:探讨早产儿感染治疗中,广谱抗菌药物疗程与肠道部分核心菌群变化及早期体质量增长的相关性。方法:选取我
院2023 年5 月-2025 年4 月收治的感染性疾病早产儿120 例,依据临床疗效和病原学结果确定的实际抗菌药物用药疗程分为
短期组(疗程≤3 d)和长期组(疗程≥7 d)各60 例。在患儿入院治疗后3、7、14 d 采集粪便样本,采用定量PCR 检测双歧杆菌、
乳酸杆菌和大肠埃希菌含量,并随访1~3 月龄的体质量。结果:治疗后3、7、14 d,长期组双歧杆菌和乳酸杆菌含量持续下降,
均低于短期组(P<0. 05);大肠埃希菌含量组间差异无统计学意义(P>0. 05)。116 例患儿完成3 个月随访,长期组体质量过度
增长发生率为15. 52%(9/ 58),高于短期组的5. 17%(3/ 58)(P<0. 05)。多因素logistic 回归校正分娩方式、喂养方式及感染严
重程度后,长疗程与3 月龄体质量过度增长风险升高相关(OR=2. 38,P<0. 05)。结论:早产儿长疗程(≥7 d)广谱抗菌药物暴
露与双歧杆菌、乳酸杆菌减少及3 月龄体质量过度增长风险升高相关,但因疗程由病情决定,该结论仍需更大样本量研究验证。 |
| 关键词: 抗菌药物暴露 肠道微生态 体质量过度增长 菌落 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2026.08.004 |
|
| 基金项目:基金项目:杭州市临平区科技计划项目,编号LPWJ2023-02-15。 |
|
| Effects of Broad-Spectrum Antibiotics Duration on Intestinal Core Flora and Early Weight Gain in PretermInfants: a Prospective Observational Study |
| Yu Junjie, Hu Wanjian, Yu Xiaolu, Bao Shanshan, Zhou Yirong |
| (Linping District Maternal and Child Health Hospital,
Hangzhou 311100, China) |
| Abstract: |
| Objective: To investigate the correlation between the duration of broad-spectrum antibiotic therapy and changes in core
intestinal microbiota and early weight gain in preterm infants with intestinal infection. Methods: A total of 120 preterm infants with
infectious diseases admitted into our hospital from May 2023 and Apr. 2025 were selected. According to the actual duration of antibiotic
use determined by clinical efficacy and etiological results, the children were divided into short-term group (duration ⩽3 d) and longterm
group (duration ⩾7 d), with 60 cases in each group. Stool samples were collected before intervention and at 3, 7, and 14 d after
intervention. Quantitative PCR was used to detect the contents of Bifidobacterium, Lactobacillus, and Escherichia coli. And follow up was
performed on body weight at 1 to 3 months of age. Results: At 3, 7, and 14 d after intervention, the contents of Bifidobacterium and
Lactobacillus in the long-term group decreased and were lower than those in the short-term group (P<0. 05). No statistically significant
difference was found in E. coli between two groups (P >0. 05). According to the 116 cases that completed 3-month follow-up, the
incidence of excessive weight gain in long-term group was 15. 52% (9/ 58), higher than 5. 17% (3/ 58) in short-term group (P <
0. 05). After adjusting for mode of delivery, feeding pattern, and infection severity by using multivariate logistic regression, long-term
treatment was associated with an increased risk of excessive weight gain at 3 months of age (OR=2. 38, P<0. 05). Conclusion: Longterm
(⩾7 d) exposure to broad-spectrum antibiotic therapy in preterm infants is associated with decreased levels of Bifidobacterium and
Lactobacillus, and excessive body weight gain at 3 months of age. However, since the duration of treatment is determined by the disease
condition, this conclusion still requires validation in larger sample size studies. |
| Key words: antibiotic exposure intestinal microecology excessive body weight gain colony |
