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| 儿科麻醉超说明书用药的循证评价与分级管理 |
| 刘蕾1,张潇月1,邢亚兵1,马瑞娟1,邢慧资1,刘晓玲1,王瑞丽1,万蒞2,王晓玲3,张胜男1 |
|
|
| (1. 郑州大学附属儿童医
院,河南省儿童医院郑州儿童医院,郑州 450018;2. 湖北省妇幼保健院,武汉 430070;3. 首都医科大学附属北京儿童医院,
北京 100045) |
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| 摘要: |
| 目的:针对儿科麻醉常用药品的超说明书用药情况,开展循证药学评价,规范麻醉常用药品在儿科人群的使用。方法:
收集郑州大学附属儿童医院的儿科麻醉超说明书用药数据,进行分类统计;查阅国内外药品的最新版药品说明书,检索
Micromedex 数据库,对于国外药品说明书未增加以及Micromedex 数据库没有收载的超说明书用药,查询医学文献进一步评价;
并依据最新循证证据实施分级管理。结果:收集超说明书用药数据,涉及超说明书用药共计55 项;依据最新循证证据19 项实
施A 级管理,31 项实施B 级管理,5 项C 级管理,其他执行D 级管理。结论:本研究为麻醉常用药品在儿科人群的超说明书应
用提供了循证证据支持,为药师处方审核及医院动态管理提供了理论依据。 |
| 关键词: 儿科 麻醉用药 超说明书 循证药学 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2026.05.005 |
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| 基金项目:基金项目:2024 年度中国医院药学高质量发展研究项目专项课题,编号NIHAZX202435;郑州市医学重点学科项目(儿科药学),编号
2023ZZSZDXK02; |
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| Evidence-Based Evaluation and Graded Management of Off-Label Drug Use in Pediatric Anesthesia |
| Liu Lei1, Zhang Xiaoyue1, Xing Yabing1, Ma Ruijuan1, Xing Huizi1, Liu Xiaoling1, Wang Ruili1, Wan Li2,
Wang Xiaoling3, Zhang Shengnan1 |
| (1. Children’ s Hospital Affiliated to Zhengzhou University, Henan Children’ s Hospital,
Zhengzhou Children’ s Hospital,Zhengzhou 450018, China; 2. Maternal and Child Health Hospital of Hubei Province, Wuhan
430070, China; 3. Beijing Children’s Hospital, Capital Medical University, Beijing 100045, China) |
| Abstract: |
| Objective: To conduct an evidence-based pharmacological evaluation of off-label use for pediatric anesthetic drugs, and to
standardize the use of common anesthetic drugs in children. Methods: Data on off-label use of pediatric anesthesia drugs in Children’s
Hospital Affiliated to Zhengzhou University were collected and categorized. The latest versions of domestic and international drug
instructions were reviewed, and the Micromedex database was retrieved. For off-label use not covered in international drug instructions or
Micromedex database, further evaluation was conducted by reviewing medical literature. Management strategies were graded based on the
latest evidence-based evidence. Results: A total of 55 off-label use cases were collected. Based on the latest evidence-based evidence,
19 cases were classified as grade A management, 31 as grade B, 5 as grade C, and the remaining as grade D. Conclusion: This study
provides evidence-based support for off-label use of common anesthetic drugs in children, offering a theoretical basis for pharmacists’
prescription reviews and hospital dynamic management. |
| Key words: Pediatrics anesthetic drugs off-label use evidence-based pharmacy |
