| 摘要: |
| 目的:评估超未成熟儿甲状腺功能,探讨左甲状腺素钠替代治疗的意义。方法:回顾性分析2021 年7 月至2024 年7 月在
首都医科大学附属北京妇产医院住院的超未成熟儿的临床资料,对其甲状腺功能、临床特点及结局进行归纳总结。结果:纳入
研究的38 例超未成熟儿中合并甲状腺功能异常患儿10 例,进行左甲状腺素钠片替代治疗的患儿9 例。根据有无甲状腺功能
异常将其分为病例组及对照组,分析比较两组患儿的临床资料及结局,结果显示,病例组患儿黄疸持续时间较长、达到全肠内营
养所需时间较长(P 分别为0. 014、0. 027)。两组患儿支气管肺发育不良脑室内出血、需要手术治疗的早产儿视网膜病发病率无
明显差异,听力筛查通过率及新生儿行为神经测定评分差异无统计学意义(均P>0. 05)。结论:超未成熟儿甲状腺功能异常即
便多数给予左甲状腺素替代治疗,仍然出现黄疸消退延迟、喂养慢;经替代治疗后,住院期间呼吸系统及神经系统相关短期结局
(颅内出血、需要手术的早产儿视网膜病、新生儿行为神经测定评分、听力筛查通过率等)与甲状腺功能正常患儿未见统计学差异。 |
| 关键词: 超未成熟儿 甲状腺功能 先天性甲状腺功能减退症 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2026.11.012 |
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| 基金项目: |
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| Retrospective Study on Thyroid Function Characteristics and Replacement Therapy in Extremely PretermInfants |
| Huang Wenqing, Liu Weiwei, Jia Xiao |
| (Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing
100026, China) |
| Abstract: |
| Objective: To evaluate the thyroid function of extremely premature infants and explore the significance of using levothyroxine
sodium for replacement therapy. Methods: Clinical data of extremely preterm infants admitted into Beijing Obstetrics and Gynecology
Hospital, Capital Medical University from Jul. 2021 to Jul. 2024 were retrospectively analyzed to summarize the thyroid function,
clinical features and outcomes. Results: Among 38 enrolled infants, 10 cases had thyroid dysfunction and 9 cases received levothyroxine
sodium replacement. Patients were stratified into case (dysfunction) group and control (normal thyroid function) group. Clinical data
and outcomes of two groups were analyzed. The case group had prolonged jaundice and delayed full enteral feeding (P=0.014 and 0.027). No
intergroup differences were found in bronchopulmonary dysplasia, intraventricular hemorrhage, surgical retinopathy of prematurity, pass
rate of hearing screening or neonatal behavioral neurological assessment scores ( P > 0. 05). Conclusion: Despite levothyroxine
replacement therapy is administered to most extremely preterm infants with thyroid dysfunction, prolonged jaundice resolution and
delayed feeding are still observed. After replacement therapy, no statistically significant differences are found in short-term respiratory
and neurological outcomes during hospitalization ( intracranial hemorrhage, surgically treated retinopathy of prematurity, neonatal
behavioral neurological assessment score, and pass rate of hearing screening) compared with infants having normal thyroid function. |
| Key words: extremely premature infants thyroid function congenital hypothyroidism |
