| 摘要: |
| 目的:探讨细菌性脑膜炎(BM)患儿血清中性粒细胞载脂蛋白(HNL)、中性粒细胞计数(ANC)、前列腺素E2(PGE2) 水
平的变化,并进一步建立BM 患儿预测转归模型。方法:选取2022 年10 月至2024 年10 月我院收治的105 例BM 患儿为BM
组,其中轻度BM 组62 例和重度BM 组43 例。另选取同期105 例体检健康儿童为对照组。根据出院时格拉斯哥结局评分
(GOS)将BM 组患儿分为预后良好组和预后不良组。采用全自动五分类血细胞计数仪检测记录ANC,酶联免疫吸附试验法检
测血清HNL、PGE2 水平。采用多因素logistic 回归分析BM 患儿预后影响因素;受试者工作特征(ROC) 曲线分析血清HNL、
ANC、PGE2 对BM 组患儿预后的预测价值。结果:BM 组血清HNL、ANC、PGE2 水平均高于对照组(P<0. 05)。重度BM 组血清
HNL、ANC、PGE2 水平较轻度BM 组升高(P<0. 05)。预后不良组BM 患儿血清HNL、ANC、PGE2 水平高于预后良好组,年龄小
于预后良好组(P<0. 05)。血清HNL、ANC、PGE2 水平是BM 患儿预后不良的危险因素(P<0. 05),三者联合预测BM 患儿预后
的曲线下面积(AUC)高于单独预测(Z =3. 413、3. 476、3. 691,P<0. 05)。结论:血清HNL、ANC、PGE2 水平与BM 患儿预后密切
相关,三者联合建立的预测转归模型可辅助预测BM 患儿预后。 |
| 关键词: 细菌性脑膜炎 中性粒细胞载脂蛋白 中性粒细胞计数 前列腺素E2 预后 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2026.07.002 |
|
| 基金项目:河北省2024 年度医学科学研究课题计划项目,编号20240277。 |
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| Predictive Value of Serum Human Neutrophil Lipocalin, Absolute Neutrophil Count, and Prostaglandin E2for Prognosis of Bacterial Meningitis in Children |
| Li Chenxi, Yang Xiaoxuan, Zhao Sai, Liu Xiao, Tang He, Jiang Tingting, Bi Jing |
| ((Baoding Hospital of Beijing
Children’s Hospital, Capital Medical University, Hebei Baoding 071000, China)) |
| Abstract: |
| Objective: To investigate the levels of human neutrophil lipocalin ( HNL), absolute neutrophil count ( ANC), and
prostaglandin E2 (PGE2) in children with bacterial meningitis (BM), and further establish a predictive outcome model for children with
BM. Methods: Totally 105 children with BM in our hospital from Oct. 2022 to Oct. 2024 were extracted as the BM group, including 62 cases
in the mild BM group and 43 cases in the severe BM group. Another 105 healthy children who experienced physical examinations were
labeled as the control group. Complying with the Glasgow Outcome Scale (GOS) at discharge, children in the BM group were assigned into
the good prognosis group and poor prognosis group. Fully automatic five class blood cell counter was performed to detect and record ANC.
Enzyme linked immunosorbent assay was used to detect serum HNL and PGE2 levels. Multivariate logistic regression was used to analyze
the prognostic factors of children with BM. Receiver operating characteristic (ROC) curve was performed to analyze the the predictive
value of serum HNL, ANC, and PGE2 for the prognosis of children with BM. Results: The serum levels of HNL, ANC, and PGE2 in BM
group were higher than those in control group (P<0. 05). The severe BM group had higher levels of HNL, ANC, and PGE2 than those in
mild BM group (P<0. 05). Children with BM in poor prognosis group had higher levels of HNL, ANC, and PGE2 than those in good
prognosis group, and the age was lower than that in good prognosis group (P<0. 05). The levels of HNL, ANC, and PGE2 were risk
factors for poor prognosis in children with BM (P<0. 05). The area under the curve (AUC) for predicting prognosis of children with BM by
combination of the three factors was higher than that of HNL, ANC, and PGE2 predicted separately (Z =3. 413, 3. 476, 3. 691, P<0. 05).
Conclusion: The levels of HNL, ANC, and PGE2 are closely related to the prognosis of children with BM. The prediction model
established by the combination of the three can provide reference for clinical auxiliary prediction of the prognosis of children with BM. |
| Key words: bacterial meningitis human neutrophil lipocalin absolute neutrophil count prostaglandin E2 prognosis |
