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| 醒脾养儿颗粒联合外周1-去氨基-8-D-精氨酸血管加压素治疗脾肾
两虚型小儿遗尿症的随机对照研究 |
| 赵晓华1,刘宝环1,房建兆1,王红岩1,黄少泽1,回娟2,王荣1,李冠慧1 |
| (1. 沧州市人民医院,河北沧州 061000;2. 沧州
市新华区南大街社区卫生服务中心,河北沧州 061000) |
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| 摘要: |
| 目的:探讨醒脾养儿颗粒联合外周1-去氨基-8-D-精氨酸血管加压素( DDAVP) 对小儿遗尿症( NE) 的干预效果,以及对
遗尿次数、实验室指标等的影响。方法:选取沧州市人民医院2022 年12 月-2025 年5 月收治的NE 患儿91 例,按随机数表法
分为DDAVP 组和观察组。DDAVP 组给予DDAVP 治疗,观察组给予DDAVP 与醒脾养儿颗粒治疗。持续治疗8 周后,评价两
组患儿遗尿次数与膀胱容量、中医证候积分、睡眠觉醒障碍、实验室指标、总有效率等。结果:治疗后,观察组患儿治疗总有效率
高于DDAVP 组(P<0. 05);遗尿次数、中医证候积分、儿童睡眠紊乱量表(SDSC)评分均低于DDAVP 组(P<0. 05);抗利尿激素
(ADH)、膀胱容量、环磷酸腺苷(cAMP)水平均高于DDAVP 组(P<0. 05)。结论:NE 患儿接受醒脾养儿颗粒与DDAVP 联合治
疗,能有效缓解症状,减少夜间遗尿次数,调节ADH、cAMP 水平,改善机体膀胱功能。 |
| 关键词: 儿童 遗尿症 醒脾养儿颗粒 外周1-去氨基-8-D-精氨酸血管加压素 抗利尿激素 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2026.08.011 |
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| 基金项目:基金项目:2022 年沧州科技计划自筹经费项目,编号222106003。 |
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| Randomized Controlled Study on Xingpi Yang’er Granules Combined with 1-Deaminization-8-D-ArginineVasopressin in the Treatment of Children with Enuresis of Spleen-Kidney Deficiency Syndrome |
| Zhao Xiaohua1, Liu Baohuan1, Fang Jianzhao1, Wang Hongyan1, Huang Shaoze1, Hui Juan2, Wang Rong1, Li
Guanhui |
| (1. Cangzhou People’s Hospital, Hebei Cangzhou 061000, China; 2. Xinhua District South Street Community Health Service
Center, Hebei Cangzhou 061000, China) |
| Abstract: |
| Objective: To explore the intervention effects of Xingpi Yang’ er granules combined with 1-deaminization-8-D-arginine
vasopressin (DDAVP) on enuresis (NE) in children, and its effects on frequency of enuresis and laboratory indicators. Methods: A
total of 91 children with NE admitted into Cangzhou People’s Hospital from Dec. 2022 to May 2025 were extracted to be divided into
DDAVP group and observation group via the random number table method. The DDAVP group received DDAVP treatment, while the
observation group was given DDAVP combined with Xingpi Yang’er granules. After 8 weeks of continuous treatment, the frequency of
nocturia, bladder capacity, traditional Chinese medicine syndrome score, sleep-wake disorder, laboratory indicators, and total effective
rate of two groups were evaluated. Results: After treatment, the total effective rate of observation group was higher than that of DDAVP
group (P<0. 05); the frequency of enuresis, traditional Chinese medicine syndrome score, and Sleep Disturbance Scale for Children
(SDSC) score in observation group were lower than those in DDAVP group (P<0. 05). The levels of antidiuretic hormone (ADH),
bladder capacity, and cyclic adenosine monophosphate (cAMP) in observation group were higher than those in DDAVP group (P <
0. 05). Conclusion: For children with NE, Xingpi Yang’er granules combined with DDAVP can effectively alleviate symptoms, reduce
the frequency of nocturnal enuresis, regulate ADH and cAMP levels, and improve the bladder function. |
| Key words: children nocturnal enuresis Xingpi Yang’er granules 1-deaminization-8-D-arginine vasopressin antidiuretic hormone |
