| 摘要: |
| 目的:探讨青紫消斑汤熏洗联合氢化可的松琥珀酸钠治疗过敏性紫癜(HSP) 的临床效果。方法:选取河北省沧州中西
医结合医院2024 年6 月-2025 年5 月收治的HSP 患儿82 例,随机分为对照组(氢化可的松琥珀酸钠)、观察组(青紫消斑汤熏
洗+氢化可的松琥珀酸钠)各41 例,比较两组患儿临床疗效、中医证候积分、炎症因子、免疫功能相关指标及不良反应发生率。
同时,采用Spearman 和Pearson 相关分析炎症和免疫相关因子与临床疗效及中医证候积分的关系。结果:观察组总有效率为
92. 68%,高于对照组的75. 61%(P<0. 05);治疗后,观察组中医证候积分、白三烯B4(LTB4)、白细胞介素-4(IL-4)、血管内皮生
长因子(VEGF)、IgA、IgE 水平均低于对照组(P<0. 05)。上述指标与中医证候积分呈正相关(P<0. 05)。治疗后,两组患儿空腹
血糖较治疗前升高,生长激素较治疗前下降(P<0. 05)。结论:青紫消斑汤熏洗联合氢化可的松琥珀酸钠治疗HSP 的临床疗效
显著,可有效缓解患儿中医证候表现,抑制体内炎症反应,调节免疫球蛋白水平,改善免疫失衡,且安全性良好。 |
| 关键词: 青紫消斑汤熏洗 氢化可的松琥珀酸钠 儿童 白三烯B4 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2026.10.010 |
|
| 基金项目:河北省中医药管理局科研计划项目,编号2025558。 |
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| Efficacy of Qingzhi Xiaoban Decoction Fumigation and Washing Combined with Hydrocortisone SuccinateSodium in the Treatment of Children with Henoch-Schönlein Purpura and Its Effects on InflammatoryImmune Indicators |
| Wang Ruobi1, Shi Jiapan2, Qian Meijia1, Liu Xingyue1, Lyu Hongyuan1, Li Dan1, Mu Chunyu1, Wang Xinyao1 |
| ((1. Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Hebei Cangzhou 061000, China; 2. First Affiliated
Hospital of North University of China, Hebei Zhangjiakou 075000, China)) |
| Abstract: |
| Objective: To explore the clinical effects of Qingzi Xiaoban decoction fumigation and washing combined with hydrocortisone
succinate sodium in the treatment of children with Henoch-Schönlein purpura (HSP). Methods: From Jun. 2024 to May 2025, totally
82 cases of children with HSP admitted into Hebei Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine were
extracted to be divided into the control group (sodium hydrocortisone succinate) and observation group (Qingzi Xiaoban decoction
fumigation and washing combined with hydrocortisone succinate sodium), with 41 cases in each group. The clinical efficacy, traditional
Chinese medicine syndrome scores, inflammatory factors, immune function-related indicators, and incidence of adverse drug reactions
were compared between two groups. Meanwhile, Spearman and Pearson correlation analysis were employed to investigate the correlation
between inflammatory, immune-related factors, clinical efficacy and traditional Chinese medicine syndrome scores. Results: The total
effective rate in observation group was 92. 68%, significantly higher than 75. 61% of control group (P<0. 05). After treatment, the
traditional Chinese medicine syndrome scores, leukotriene B4 ( LTB4), interleukin-4 ( IL-4), vascular endothelial growth factor
(VEGF), IgA, and IgE levels in observation group were lower than those in control group (P <0. 05). The above indicators were
positively correlated with traditional Chinese medicine syndrome scores (P<0. 05). After treatment, the fasting blood glucose levels in
both groups increased compared with before treatment, while the growth hormone levels decreased compared with before treatment (P<0.05).
Conclusion: The efficacy of Qingzi Xiaoban decoction fumigation and washing combined with hydrocortisone succinate sodium in the
treatment of children with HSP is significant, which can effectively alleviate traditional Chinese medicine syndrome manifestations,
inhibit systemic inflammatory responses, regulate immunoglobulin levels, improve immune imbalance with favorable safety. |
| Key words: Qingzi Xiaoban decoction fumigation and washing hydrocortisone succinate sodium children leukotriene B4 |
