| 本文已被：浏览 90次 下载 72次 |
码上扫一扫！ |
| 1 例激素耐药型肾病综合征合并轮状病毒腹泻患儿的他克莫司血药 浓度监测并文献复习 |
| 王洋1,2,吴丹1,刘小会1,孙嫱1,郭鹏1,赵一鸣1,魏京海1 |
| (1. 国家儿童医学中心,首都医科大学附属北京儿童医院,北京 100045;2. 濮阳市人民医院,河南濮阳 457000) |
|
| 摘要: |
| 目的:临床药师参与 1 例激素耐药型肾病综合征患儿的药物治疗方案调整,为他克莫司用药监护提供参考。 方法:临床 药师根据患儿他克莫司血药浓度监测结果并结合文献证据协助临床医师进行个体化药物调整,同时为患儿提供全面的药学监 护,推荐下调他克莫司剂量为 0. 5 mg,q12h,并在患儿胃肠道功能恢复后根据谷浓度调整他克莫司剂量。 结果:医师采纳临床药 师建议,后患儿腹泻好转,他克莫司血药浓度维持稳定。 结论:轮状病毒腹泻可能升高他克莫司的血药浓度,在腹泻期间及恢复 期应密切监测他克莫司血药浓度,并进行个体化的药物剂量调整。 |
| 关键词: 肾病综合征 儿童 轮状病毒感染 他克莫司 |
| DOI：10.13407/j.cnki.jpp.1672-108X.2026.09.011 |
|
| 基金项目:“儿科超说明书用药”临床研究的规范化管理与监管策略研究,编号 2025-Y-Y-007;中国儿童 UDCA 临床用法用量多中心调查研究方案项目。 |
|
| Monitoring of Tacrolimus Blood Concentration in a Child with Steroid-Resistant Nephrotic Syndrome Complicated by Rotavirus Diarrhea: a Case Report and Literature Review |
| Wang Yang1,2 , Wu Dan1 , Liu Xiaohui1 , Sun Qiang1 , Guo Peng1 , Zhao Yiming1 , Wei Jinghai1 |
| (1. National Center for Children’s Health, Beijing Children’ s Hospital, Capital Medical University, Beijing 100045, China; 2. Puyang People’ s Hospital, Henan Puyang 457000, China) |
| Abstract: |
| Objective: To analyze the involvement of clinical pharmacists in adjusting the drug treatment regimen for a child with steroid-resistant nephrotic syndrome, and to provide reference for therapeutic drug monitoring of tacrolimus. Methods: Based on tacrolimus trough concentration monitoring and evidence from the literature, the clinical pharmacists assisted clinicians in implementing individualized dose adjustments and provided comprehensive pharmaceutical care. A reduction of the tacrolimus dose to 0. 5 mg every 12 h was recommended, with subsequent dose titration according to trough concentrations after recovery of gastrointestinal function. Results: The clinicians adopted the clinical pharmacist’ s recommendations. The symptoms of diarrhea in the child subsequently improved, and tacrolimus blood concentrations remained stable. Conclusion: Rotavirus-associated diarrhea may increase tacrolimus blood concentrations. Close monitoring of tacrolimus levels and individualized dose adjustments are warranted during episodes of diarrhea and throughout the recovery period. [Keywords]nephrotic syndrome; chil |
| Key words: ]nephrotic syndrome children rotavirus infection tacrolimus |
