| 摘要: |
| 目的:建立诊断模型,探讨传统炎症指标联合新型炎症指标在儿童肺炎支原体肺炎(MPP) 合并消化道损伤中的诊断价
值。方法:选取我院2021 年8 月至2024 年8 月收治的100 例MPP 患儿,依据是否合并消化道损伤分为观察组(50 例)与对照
组(50 例)。收集患儿一般资料,检测C 反应蛋白(CRP)、降钙素原(PCT)及新型指标血清淀粉样蛋白A(SAA)、髓系细胞触发
受体-1(TREM-1)水平,记录观察组患儿消化道损伤临床表现。结果:观察组CRP 水平为(38. 60±13. 65) mg/ L,高于对照组的
(14. 90±8. 22)mg/ L;观察组PCT 为(0. 61±0. 24) ng/ mL,高于对照组的( 0. 20±0. 09) ng/ mL;观察组SAA 水平为( 132. 70±
38. 45)mg/ L,高于对照组的( 56. 35± 21. 72) mg/ L; 观察组TREM-1 水平为( 88. 45± 19. 58) pg/ mL, 高于对照组的( 40. 30±
11. 82)pg/ mL,差异均有统计学意义(均P<0. 05)。观察组治疗3、5、7 天各指标恢复速度慢于对照组(P<0. 05)。多因素logistic
回归显示,CRP、PCT 及SAA 是影响MPP 合并消化道损伤诊断的独立危险因素(P<0. 05)。受试者工作特征(ROC)曲线显示,
CRP、PCT 联合SAA 的曲线下面积(AUC)达0. 944,诊断价值优于单一指标组合(P<0. 01)。结论:CRP、PCT 联合SAA 监测有
助于诊断儿童MPP 合并消化道损伤,为临床早期干预提供参考。 |
| 关键词: 儿童 肺炎支原体肺炎 消化道损伤 炎症指标 诊断模型 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2026.10.007 |
|
| 基金项目:浙江省医学会临床医学科研专项资金项目,编号2023ZYC-A183 |
|
| Exploration and Construction of Inflammatory Marker Prediction Model for Children with MycoplasmaPneumoniae Pneumonia Complicated with Digestive Tract Injury |
| Du Lu, Wang Xiaoyan, Pan Boting |
| ((Shaoxing Wenli Medical College Affiliated Hospital, Zhejiang Shaoxing 312000, China)) |
| Abstract: |
| Objective: To establish the diagnostic model to explore the diagnostic value of traditional inflammatory indicators combined
with novel inflammatory indicators in children with Mycoplasma pneumoniae pneumonia (MPP) complicated with digestive tract injury.
Methods: A total of 100 children with MPP admitted into our hospital from Aug. 2021 to Aug. 2024 were enrolled to be divided into the
observation group (50 cases with digestive tract injury) and control group (50 cases without digestive tract injury). General clinical data detection of CRP, PCT and SAA yielded an area under the curve (AUC) of 0. 944, exhibiting superior diagnostic performance compared
with single-biomarker assays (P<0. 01). Conclusion: CRP, PCT combined with SAA can accurately diagnose pediatric MPP complicated
with digestive tract injury, providing reliable reference for early clinical intervention.
were collected, and serum levels of C-reactive protein (CRP), procalcitonin (PCT), serum amyloid A (SAA) and myeloid cell trigger
receptor-1 (TREM-1) were detected. Clinical manifestations of digestive tract injury in observation group were recorded. Results: The
CRP level in observation group was (38. 60±13. 65) mg/ L, higher than (14. 90±8. 22) mg/ L of control group; the PCT level in
observation group was (0. 61±0. 24) ng/ mL, higher than (0. 20±0. 09) ng/ mL of control group; the SAA level in observation group was
(132. 70±38. 45) mg/ L, higher than (56. 35±21. 72) mg/ L of control group; the TREM-1 level in observation group was (88. 45±
19. 58) pg/ mL, higher than (40. 30±11. 82) pg/ mL of control group, the differences were statistically significant (P<0. 05). The
descending rates of all four biomarkers at the 3rd , 5th and 7th day after treatment were markedly slower in the observation group (P<
0. 05). Multivariate logistic regression analysis revealed that CRP, PCT and SAA were independent risk factors influencing the diagnosis
of MPP combined with digestive tract injury (P<0. 05). Receiver operating characteristic (ROC) curve demonstrated that the combined |
| Key words: children Mycoplasma pneumoniae pneumonia digestive tract injury inflammatory markers diagnostic model |
