| 摘要: |
| 目的:探讨儿童孤独症谱系障碍(ASD)共患抽动障碍(TD)的临床效果及安全性。方法:选取我院2024 年3 月-2025 年
9 月收治的ASD 共患TD 患儿69 例,采用随机数表法分为对照组(35 例,2 例脱落)与观察组(34 例,2 例脱落)。两组均实施常
规康复治疗,对照组加用阿立哌唑,观察组在对照组基础上联用菖麻熄风片,疗程12 周。比较两组治疗前后耶鲁综合抽动严重
程度量表(YGTSS)评分、中医证候积分、血清神经递质(5-羟色胺及多巴胺)、孤独症诊断观察量表、儿童孤独症评定量表、儿童
睡眠习惯问卷及父母压力指数量表简版评分,并记录临床疗效、不良反应、复发情况。结果:治疗后,两组各项评估指标均改善,
且观察组改善幅度均大于对照组(均P<0. 05);两组不良反应发生率比较差异无统计学意义(P>0. 05)。结论:菖麻熄风片联合
阿立哌唑治疗ASD 共患TD 的临床疗效优于单用阿立哌唑,可更有效缓解抽动症状与孤独症核心社交障碍,改善睡眠质量及情
绪行为,且不会增加不良反应。 |
| 关键词: 菖麻熄风片 阿立哌唑 孤独症谱系障碍 抽动障碍 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2026.08.007 |
|
| 基金项目:基金项目:国家自然科学基金项目,编号82560240;广西自然科学基金区域高发疾病研究联合专项资助,编号2023GXNSFBA026119;广西医
科大学青年科学基金项目,编号GXMUYSF202364;广西壮族自治区医疗卫生重点学科建设项目,桂卫教发〔2022〕4 号。 |
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| Randomized Double-Blind Controlled Study of Changma Xifeng Tablets Combined with Aripiprazole in theTreatment of Children with Autism Spectrum Disorder Complicated with Tic Disorder |
| Li Xin, Chen Zaijuan, Song Meining, Shi Dongliu, Zhang Jian |
| (The Second Affiliated Hospital of Guangxi Medical
University, Nanning 530007, China) |
| Abstract: |
| Objective: To explore the clinical efficacy and safety of Changma Xifeng tablets combined with aripiprazole in the treatment
of children with autism spectrum disorder (ASD) complicated with tic disorder (TD). Methods: A total of 69 children with ASD and
TD admitted into our hospital from Mar. 2024 to Sept. 2025 were extracted to be randomly divided into control group (35 cases, with 2
cases dropout) and observation group (34 cases, with 2 cases dropout) via the random number table method. Both groups received
conventional rehabilitation treatment. The control group was additionally treated with aripiprazole, while the observation group was given
Changma Xifeng tablets on the basis of control group. The treatment course was 12 weeks for both groups. Changes in multiple evaluation
indicators before and after treatment were compared between two groups, including Yale Global Tic Severity Scale (YGTSS) score,
traditional Chinese medicine syndrome score, serum neurotransmitters ( 5-hydroxytryptamine and dopamine), Autism Diagnostic
Observation Scale, Childhood Autism Rating Scale, Children’ s Sleep Habits Questionnaire, and Parenting Stress Index. Clinical
efficacy, adverse drug reactions and recurrence situations were recorded. Results: After treatment, all the evaluation indicators of both
groups were improved, and the improvement degree in observation group was greater than that in control group (P<0. 05). There was no
statistically significant difference in the incidence of adverse drug reactions between two groups (P>0. 05). Conclusion: The clinical
efficacy of Changma Xifeng tablets combined with aripiprazole in the treatment of children with ASD and TD is better than that of
aripiprazole alone, which can more effectively alleviate tic symptoms and core social disorders, improve sleep quality and emotional
behavior, without increasing adverse drug reactions. |
| Key words: Changma Xifeng tablets aripiprazole autism spectrum disorder tic disorder |
