| 摘要: |
| 目的:评价母乳乳清蛋白对儿童病毒性上呼吸道感染的辅助治疗效果,明确其改善发热和早期症状的特异性及安全性。
方法:选取我院2025 年4-11 月收治的89 例3~8 岁病毒性上呼吸道感染患儿,其中72 例完成研究,分为对照组38 例和观察组
34 例。对照组给予常规抗病毒及对症治疗,观察组在对照组治疗基础上加用母乳乳清蛋白口服。连续治疗5 d,比较两组患儿
治疗后的临床症状及严重程度的好转时间。结果:观察组治疗后的退热时间早于对照组(P<0. 05),年龄亚组间退热效果比较
差异无统计学意义(P>0. 05),治疗后的第2 天症状好转情况优于对照组(P<0. 05)。结论:母乳乳清蛋白作为辅助治疗手段,
可有效缩短儿童病毒性上呼吸道感染发热时间,改善病程早期症状严重程度,安全性良好,具有较高的临床应用价值。 |
| 关键词: 母乳乳清蛋白 儿童 病毒 上呼吸道感染 发热 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2026.10.002 |
|
| 基金项目:国家自然科学基金,编号82502128;国家重点研发计划,编号2023YFC2706505;上海市科学技术委员会科技计划,编号
24YF2727200。 |
|
| Randomized Controlled Study on Human Milk Whey Protein Combined with Conventional Therapy for Viral Upper Respiratory Tract Infections in Children |
| Song Guochao, Liao Lianghong, Ding Fei, Yin Ruotong, Zhou Xinyu, Zhan Zhiyan, Hong Li, Zhang Hao |
| ((Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China)) |
| Abstract: |
| Objective: To evaluate the adjuvant therapeutic effects of human milk whey protein on viral upper respiratory tract infection
in children, and to clarify its specificity and safety in alleviating fever and improving early symptoms. Methods: A total of 89 children
aged from 3 to 8 years admitted to our hospital from Apr. to Nov. 2025 were selected, of which 72 cases completed the study, including
38 cases in the control group and 34 cases in the observation group. The control group was given routine antiviral and symptomatic
treatment, while the observation group was treated with human milk whey protein orally on the basis of the control group. After 5 d of
continuous treatment, the improvement time of clinical symptoms and severity after treatment were compared between two groups.
Results: The fever duration in observation group was significantly shorter than that of control group (P < 0. 05 ). There was no
statistically significant difference in antipyretic effects among different age subgroups (P >0. 05), and the improvement of symptom
severity on the 2nd d after treatment was significantly better than that of the control group (P <0. 05). Conclusion: As the adjuvant
therapy, breast milk whey protein can effectively shorten the fever time of viral upper respiratory tract infection in children, improve the
severity of symptoms in the early stage of the disease, with higher safety and clinical application value. |
| Key words: human milk whey protein children virus upper respiratory tract infection fever |
