| 摘要: |
| 目的:了解我院儿童药品不良反应(ADR)的发生情况及特点,为临床合理用药及药品安全性评价提供参考。方法:采用回顾性研究方法,对我院2014年上报至国家药品不良反应监测中心的361例ADR报告进行分析和归纳。结果:361例ADR主要集中在6岁以下患儿(68.98%);涉及16类药品、96个品种,主要为抗感染药物(60.11%),其次为中药(13.02%)、抗肿瘤药物(5.26%);给药途径主要为静脉给药(85.32%);临床表现主要为皮肤及其附件损害(73.96%),其次为全身性损害;医师和药师为ADR报告的主体,ADR类型主要为一般ADR(98.61%)。结论:应重点加强儿童群体ADR的监测,关注儿童专科用
药ADR,强化临床药学监护,以促进临床安全合理用药。 |
| 关键词: 药品不良反应 合理用药 儿童 监测 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2017.03.014 |
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| 基金项目:南京医科大学科技发展基金面上项目,编号2015NJMU068 |
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| Retrospective Analysis of 361 Cases of Children ADR Reports in Our Hospital |
| Wang Xuan, Xu Jin, Xu Jing |
| (Children's Hospital of Nanjing Medical University, Jiangsu Nanjing 210008, China) |
| Abstract: |
| Objective: To investigate the regularity and characteristics of adverse drug reactions (ADR) occurred in children, in an attempt to provide reference for rational drug use and safety evaluation. Methods: A total of 361 ADR reports of 2014 in our hospital were analyzed and summarized by using retrospective study method. Results: Of the total 361 ADR cases, children below 6 years old occurred most. There were 96 types of drugs, 85.32% were induced by intravenous dripping which was the main ADR鄄inducing route of
administration. In the ADR-involving drugs, anti-infective drugs (60.11%) were the most, traditional Chinese medicine and anti-tumor agents accouted for 13.02% and 5.26% respectively. The lesion of skin and its appendants accounted for 73.96%, and the next was systemic damage. The most types of ADR was general ADR, accounted for 98.16%. Conclusion: Great importance should be attached to enhance specialty ADR monitoring in children, so as to promote the clinical rational drug use and ensure medication safety. |
| Key words: adverse drug reactions rational drug use children monitoring |
