| 摘要: |
| 目的:探讨大剂量甲泼尼龙治疗睡眠期癫痫性电持续状态(ESES)的临床疗效。方法:收集2010年1月至2015年3月在我院神经内科诊断为ESES 的癫痫患儿的临床资料,治疗组12例给予大剂量甲泼尼龙治疗,同期诊断为ESES未采用激素治疗的患儿15例作为对照组,比较两组患儿的临床疗效,观察癫痫发作控制情况及脑电图ESES改善情况。结果:治疗组患儿总有效率为91.7%,其中ESES完全消失率为66.7%;对照组总有效率为46.7%,其中ESES完全消失率为20.0% (P<0.05)。结论:甲泼尼龙冲击治疗伴有ESES 的癫痫患儿疗效显著,癫痫发作及ESES 现象改善明显。 |
| 关键词: 甲泼尼龙 睡眠期癫痫性电持续状态 儿童 |
| DOI：10.13407/j.cnki.jpp.1672-108X.2017.06.003 |
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| 基金项目: |
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| Methylprednisolone Therapy for Electrical Status Epilepticus during Sleep |
| Chen Hui, Liu Ping, Chen Jialei, Hu Wenguang, Zhou Wenzhi |
| (Chengdu Women and Children's Central Hospital, Sichuan Chengdu 610019, China) |
| Abstract: |
| Objective: To discuss the clinical efficacy of methylprednisolone pulse therapy for electrical status epilepticus during sleep (ESES). Methods: Collected the epilepsy children's clinical data from January 2010 to March 2015, which have diagnosed ESES. Given methylprednisone pulse treatment of children as treatment group (12 cases), during the same period diagnosis of ESES without the use of hormone treatment of children as control group (15 cases). The clinical efficacy, the seizure control and improvement of ESES phenomena of EEG before and after methylprednisolone pulse therapy were compared. Results: The total efficiency was 91.7%, including the phenomenon of ESES disappeared completely was 66.7% in the treatment group. In the control group, the total efficiency was 46.7%, but the phenomenon of ESES disappeared completely was only 20.0% (P<0.05). Conclusion: The curative effect of the methylprednisolone pulse therapy for ESES is distinct, epilepsy seizure and the ESES phenomenon are improved obviously. |
| Key words: methylprednisolone electrical status epilepticus during sleep children |
