| 摘要: |
| 目的:分析小儿支气管肺炎致病菌耐药性及免疫治疗的临床价值。方法:选取我院2010-2013年诊断为小儿支气管肺炎患儿93例,采集患儿深部痰标本进行细菌培养与鉴定、药敏试验分析,并对观察组患儿行免疫治疗,分析免疫治疗效果。结果:93例患儿革兰阳性菌阳性率46郾2%,革兰阴性菌阳性率52.7%,真菌阳性率1.1%,所有致病菌中流感嗜血杆菌居首位,排在前三位的致病菌分别为流感嗜血杆菌、肺炎链球菌和卡他莫拉菌。药敏试验分析结果显示,肺炎链球菌、流感嗜血杆菌、肺炎克雷伯菌、铜绿假单胞菌、大肠埃希菌及金黄色葡萄球菌均对氨苄西林高度耐药,对左氧氟沙星呈低度耐药。观察组患儿治疗后免疫细胞因子CD+3、CD+4以及CD+4/CD+8 均较治疗前明显改善,与对照组比较差异有统计学意义(P<0.05);观察组患儿退热时间、咳嗽消失时间、肺部啰音消失时间及总住院时间均较对照组明显缩短(P<0.05)。结论:小儿支气管肺炎致病菌及其耐药性发生重大变迁,应用免疫治疗能有效改善患儿机体免疫力,临床效果显著。 |
| 关键词: 支气管肺炎 耐药性 免疫治疗 儿童 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2017.10.007 |
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| 基金项目: |
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| Drug Resistance of Pathogenic Bacteria in Children with Bronchial Pneumonia and the Value of Immunotherapy |
| Zhang Tao, He Fangzhi |
| (Xi'an Children's Hospital, Shaanxi Xi'an 710054, China) |
| Abstract: |
| Objective: To analyze the drug resistance of pathogenic bacteria in children with bronchial pneumonia and the value of immunotherapy. Methods: Collected 93 cases of children with bronchial pneumonia in our hospital from 2010 to 2013, then collected sputum samples from children, cultured and identified bacteria in biological laboratory, and analyzed the drug sensitive test. The observation group was treated with immunotherapy, then to analyze the effect of immunotherapy. Results: The positive rate of gram positive bacteria was 46.2% in 93 cases, the positive rate of gram negative bacteria was 52.7%, and the positive rate of fungal bacteria was 1.1%. Haemophilus influenza was the most common among all the pathogenic bacteria, and the top three pathogenic bacteria were Haemophilus influenza, Streptococcus pneumoniae and Moraxella catarrhalis. The results of drug sensitive test showed that Streptococcus pneumonia, Haemophilus influenza, Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli and Staphylococcus aureus were highly resistant to ampicillin and low-level resistant to levofloxacin. The immune cytokines CD+3 , CD+4 and CD+4 / CD+8 of the observation group after treatment in children were lower than those before treatment, it had significant difference compared with the control group (P<0.05). The main clinical symptoms disappeared time (fever, cough, pulmonary rale) and hospitalization time of observation group were significantly shorter than those of the control group (P<0.05). Conclusion: The pathogenic bacteria and drug resistance in children with bronchial pneumonia have changed, and the application of immunotherapy can effectively improve the immune system, and the clinical effect is significant. |
| Key words: bronchial pneumonia drug resistance immunotherapy children |
