| 摘要: |
| 目的:了解婴儿感染B族链球菌(GBS)的红霉素、克林霉素耐药率及大环内酯鄄林可酰胺鄄链阳菌素B(MLSB)类抗菌药
物耐药表型。方法:采用纸片扩散法检测婴儿感染GBS菌株对红霉素、克林霉素的敏感性,D试验检测红霉素对克林霉素的诱
导耐药性。结果:本研究纳入的患儿中男16例,女15例,年龄3 h~5个月。GBS 对红霉素、克林霉素的耐药率分别为80.6%、
77.4%;对红霉素、克林霉素同时敏感的GBS 3株,占9.7%;对红霉素耐药、对克林霉素敏感的2 株,占6.5%。23 例(92.0%)
内在型耐药(cMLSB),2 例(8.0%)M 型耐药,未发现诱导型耐药。结论:婴儿感染的B 族链球菌对红霉素、克林霉素耐药率高,
MLSB 耐药表型以cMLSB 为主,未发现诱导型耐药。 |
| 关键词: 婴儿 B 族链球菌 克林霉素 耐药 |
| DOI：10.13407/j.cnki.jpp.1672-108X.2017.05.001 |
|
| 基金项目:深圳市科技计划项目,编号JCYJ20150403100317058;深圳市卫生计生系统科研项目,编号201402045。 |
|
| Inducible Resistance to Clindamycin in Group B Streptococcus Isolated from Infants in Shenzhen |
| Zhang Jiaosheng1,Wang Hongmei1,Dong Yimei1,Zhang Lei1,Zhang Ruimu2,Deng Jikui1 |
| (1.Shenzhen Children's Hospital,
Guangdong Shenzhen 518038,China;2.Shantou University Clinical Institute Pediatrics,Guangdong Shenzhen 518038,China)) |
| Abstract: |
| Objective: To explore the resistance rate of group B Streptococcus (GBS) to erythromycin and clindamycin and phenotype
of resistance to macrolides, lincosamides and type B streptogramin(MLSB)in infected infants. Methods: The antimicrobial susceptibility
of GBS to erythromycin and clindamycin were determined by the disk diffusion technique in Mueller Hinton agar. The inducible
resistance of erythromycin to clindamycin was detected by D test. Results: Thirty one strains were isolated from 31 children (16 boys,
15 girls). The ages ranged from 3 h to 5 months. Among the 31 GBS-positive cultures, erythromycin resistance was found in 25 strains
(80.6%), clindamycin resistance was found in 24 strains(77.4%). Three GBS isolates were susceptible to both erythromycin and
clindamycin. Two isolates were resistant to erythromycin whilst susceptible to clindamycin. Among the 25 erythromycin鄄resistant isolates,
the constitutive MLSB (cMLSB) was indentified in 23 cases(92.0%). The iMLSB phenotype was not found. Conclusion: Rates of
GBS resistance to erythromycin and clindamycin in infants are high. The cMLSB phenotype is common and iMLSB is not found. |
| Key words: infant group B streptococcus clindamycin resistance |
