| 摘要: |
| 目的:分析并探究不同分娩方式对新生儿出生后3 d内肠道菌群定植及大便性状的影响。方法:选取2015年8-12月于我院出生的86例足月新生儿作为研究对象,其中经剖宫产分娩的49例新生儿纳入剖宫产组,经阴道自然分娩的37例新生儿纳入自然分娩组,分别采集新生儿分娩后3 d内每天的大便标本并对其性状进行评分,采用实时荧光定量技术对大便中的双歧杆菌、乳酸杆菌进行定量检测。结果:剖宫产组与自然分娩组大便频率为(2.8±1.1) 次/天 vs (2.4±0.9) 次/天、性状评分(2.9±0.4)分 vs (3.0±0.5)分(P>0.05);剖宫产组患儿大便pH高于自然分娩组(6.9±1.0 vs 5.9±0.7,P<0.05)。剖宫产组与自然分娩组生后第1天粪便双歧杆菌数量差异不明显[(5.63±0.65)lg拷贝数/g vs (5.70±0.72)lg拷贝数/g,P>0.05],但生后第2天、第3天剖宫产组的双歧杆菌数量少于自然分娩组[(6.34±1.01) lg拷贝数/g vs (7.38±1.11) lg拷贝数/g、(6.61±1.07) lg拷贝数/g vs (7.81±1.31)lg拷贝数/g],差异有统计学意义(P<0.05);而生后3 d内,生后第1天、第2天、第3天剖宫产组的乳酸杆菌数量始终少于自然分娩组[(4.62±0.72)lg拷贝数/g vs (5.81±0.39)lg拷贝数/g,(4.70±0.82)lg拷贝数/g vs (6.35±0.98)lg拷贝数/g、(5.14±0.54)lg拷贝数/g vs (6.93±0.34)lg拷贝数/g],差异有统计学意义(P<0.05)。结论:自然分娩有利于新生儿早期肠道菌群的定植,而剖宫产则会影响这些菌群的正常定植。 |
| 关键词: 剖宫产 新生儿 肠道菌群 |
| DOI：doi: 10.13407/j.cnki.jpp.1672-108X.2017.12.002 |
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| 基金项目: |
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| Effect of Delivery Modes on the Intestinal Flora in 3 Days Infants |
| Wu Shuli, Zhu Hua |
| (The Inner Mongolia Autonomous Region People's Hospital, Inner Mongolia Hohhot 010017, China) |
| Abstract: |
| Objective: To analyze and explore the effects of different delivery modes on the colonization of intestinal flora and the characters of feces in the infants within 3 days after birth. Methods: Eighty-six cases of full-term newborns were selected as the objects from August to December 2015 in our hospital, 49 cases with the caesarean birth were divided into caesarean birth group and 37 cases with vaginal delivery were divided into the vaginal delivery group. Neonatal stool specimens were collected within 3 days after delivery and to evaluate its characters, quantitative detection of fecal Bifidobacterium and Lactobacillus were tested by real-time fluorescent quantitative
technology. Results: The stool frequency, characters scores of caesarean birth group and natural birth group were (2.8.1.1) times/day vs. (2.4±0.9) times/day, (2.9±0.4) scores vs. (3.0±0.5) scores (P>0.05), and fecal pH of caesarean birth group was significantly higher than that of vaginal delivery group (P<0.05). There was no significant difference of the quantity of Bifidobacterium in caesarean birth group ((5.63±0.65) lg copy/g) and vaginal delivery group ((5.70±0.72) lg copy/g) on day 1 (P>0.05). But the quantity of Bifidobacterium in caesarean birth group were significantly less than vaginal delivery group ((6.34±1.01) lg copy/g vs. (7.38±1.11) lg copy/g, (6.61±1.07) lg copy/g vs. (7.81±1.34) lg copy/g) on day 2 and day 3 (P<0.05). The quantity of Lactobacillus in caesarean birth group were significantly less than vaginal delivery group ((4.62±0.72) lg copy/g vs. (5.81±0.39) lg copy/g, (4.70±0.82) lg copy/g vs. (6.35±0.98) lg copy/g, (5.14±0.54) lg copy/g vs. (6.93±0.34) lg copy/g) on day 1, day 2 and day 3 (P<0.05). Conclusion: Natural delivery is beneficial to the colonization of early neonatal intestinal flora, while the cesarean section will affect the normal colonization of intestinal flora. |
| Key words: cesarean section infants intestinal flora |
