| 摘要: |
| [摘要]目的:探讨影响儿童Ⅲ期手足口病预后的危险因素。方法:回顾性分析重庆医科大学附属儿童医院重症医学科2011年1月至2015年12月收治的90例Ⅲ期手足口病患儿的临床资料。根据临床结局将患儿分为死亡组和存活组,比较两组患儿在临床症状体征、辅助检查结果方面的差异,选择单因素分析有统计学意义的指标,采用非条件Logistic回归分析影响芋期手足口病患儿预后的独立危险因素。 结果:死亡组和存活组性别、发病时间、入院时小儿危重病例评分(PCIS)、白细胞计数、血小板计数、血糖峰值、乳酸、肌酸激酶同工酶(CK鄄MB)、最大心率以及肺水肿、呼吸衰竭、循环衰竭、入院时昏迷发生率比较差异有统计学意义(P<0.05)。 多因素非条件Logistic回归分析结果显示,循环衰竭[OR=9.785,95% CI(2.457,38.959)]、乳酸水平[OR=1.310,95% CI(1.022,1.681)]、白细胞计数[OR=1.156,95% CI(1.025,1.303)]、入院时 PCIS[OR=0.866,95% CI(0.783,0.957)]是Ⅲ期手足口病患儿预后的独立危险因素。结论:有循环障碍、血乳酸水平、白细胞计数升高及入院时PCIS低提示Ⅲ期手足口病患儿预后不良。 |
| 关键词: 手足口病 预后 危险因素 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2018.02.008 |
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| 基金项目: |
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| The Prognosis Risk Factors of Hand-Foot-Mouth Disease in Stage Ⅲ |
| Tang Li 1, Liu Yajun 2, Yang Ming 1, Liu Chengjun 1, Xu Feng 1 |
| (1. Xi'an Children's Hospital, Shaanxi Xi'an 710000, China; 2. People's Hospital of Guangyuan City, Sichuan Guangyuan 628000, China; 3. Children's Hospital of Chongqing Medical University, Chongqing 400014, China) |
| Abstract: |
| [Abstract]Objective: To explore the influencing factors of prognosis of hand-foot-mouth disease (HFMD) in stage Ⅲ. Methods: The
clinical data of 90 cases with HFMD treated in the Children's Hospital of Chongqing Medical University from January 2011 to December
2015 were analyzed retrospectively. All cases were divided into death group and survival group according to the outcome. Then, we used univariate and multiple non-conditional logistic regression analysis of risk factors affecting outcome. Results: Significant statistical differences were found in the comparison of admission time, pulmonary edema, respiratory failure, circulatory failure, blood glucose level, Pediatric critical illness score(PCIS)at admission, the maximum heart rate (HR), white blood cell count, CK-MB level, lactate level (P<0.05). The multiple non-conditional Logistic regression analysis shows that; circulatory failure [OR=9.785, 95% CI(2.457, 38.959)], lactate serum level [OR=1.310, 95% CI (1.022, 1.681)], WBC count [OR=1.156, 95% CI (1.025, 1.303)], PCIS score at admission [OR=0.866, 95% CI (0.783, 0.957)] were independent risk factors for HFMD in stage Ⅲ.Conclusion: Factors influence the outcome of HMFD including circulatory failure, blood lactate level, WBC count and PCIS score at admission. |
| Key words: hand-foot-mouth disease prognosis risk factors |
