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| 病毒性脑炎患儿脑脊液和血清中IFN-α和S100B蛋白的表达及临床意义 |
| 胡伟伟,刘志广,李伟,袁方,刘丙丽,刘君,朱亮,王江波,曹培卫 |
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| (徐州市中心医院,江苏徐州 221009) |
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| 摘要: |
| 目的:探讨病毒性脑炎患儿脑脊液和血清中琢干扰素(IFN-α)和S100B蛋白水平及临床意义。方法:选择我院收治的病毒性脑炎患儿80例为研究组,同时纳入50例体检健康儿童为对照组。比较两组儿童不同症状、阶段及预后患儿脑脊液和血清中IFN-α和S100B蛋白水平。结果:与对照组比较,研究组患儿脑脊液和血清IFN-α和S100B蛋白水平均显著升高,差异有统计学意义(P<0.01);重症组患儿脑脊液和血清中IFN-α和S100B蛋白水平显著高于轻症组(P<0.01);恢复期患儿脑脊液和血清中IFN-α和S100B蛋白水平显著低于急性期(P<0.01)。1年随访发现,预后差的患儿在入院时脑脊液和血清中IFN-α和S100B蛋白水平显著高于预后良好患儿(P<0.01)。多元线性回归分析显示,重症及急性期为IFN-α和S100B蛋白水平升高的独立影响因素(P<0.05)。结论:脑脊液和血清中IFN-α和S100B蛋白水平变化对评价病毒性脑炎的病情、预后有重要临床价值。 |
| 关键词: 病毒性脑炎 琢干扰素 S100B蛋白 脑脊液 |
| DOI：10.13407/j.cnki.Jpp.1672-108X.2017.09.001 |
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| 基金项目:徐州市科技项目,编号KC14SH029 |
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| Expression and Clinical Significance of IFN-α and S100B Proteins in Cerebrospinal Fluid and Serum of Children with Viral Encephalitis |
| Hu Weiwei, Liu Zhiguang, Li Wei, Yuan Fang, Liu Bingli, Liu Jun, Zhu Liang, Wang Jiangbo, Cao Peiwei |
| (Xuzhou Central Hospital, Jiangsu Xuzhou 221009, China) |
| Abstract: |
| Objective: To investigate the clinical significance and expression of IFN-α and S100B proteins levels in cerebrospinal fluid and serum in children with viral encephalitis. Methods: Eighty children with viral encephalitis were selected as observation group from our hospital, and at the same time 50 healthy children were selected as control group. The levels of IFN-αand S100B proteins in cerebrospinal fluid and serum were compared between the two groups. The levels of IFN-α and S100B proteins in cerebrospinal fluid and serum were compared in different symptoms, phases and prognosis. Results: Compared with the control group, the levels of IFN-α and S100B proteins in cerebrospinal fluid and serum in observation group were significantly increased, the differences were statistically significant (P<0.01). The levels of IFN-αand S100B proteins in cerebrospinal fluid and serum in severe group were significantly higher than the mild group (P<0.01). The levels of IFN-α and S100B proteins in cerebrospinal fluid and serum in recovery phase were significantly lower than those in acute phase (P<0.01). The 1 year follow-up showed that the levels of IFN-α and S100B proteins in cerebrospinal fluid and serum of children with poor prognosis were significantly higher than those with good prognosis (P<0.01). Multivariate linear regression analysis showed that the severe and acute phases were independent risk factors affecting the rise of IFN-α and S100B proteins levels (P<0.05). Conclusion: The changes of IFN-α and S100B proteins in cerebrospinal fluid and serum have important clinical value in the evaluation of the condition and prognosis of viral encephalitis. |
| Key words: viral encephalitis IFN-α S100B proteins cerebrospinal fluid |
