| 摘要: |
| 目的:系统评价益生菌预防新生儿坏死性小肠结肠炎(NEC) 的有效性和安全性。方法:计算机检索PubMed、EMBase、
the Cochrane Library、Web of Science、中国知网、维普、万方、中国生物医学文献数据库中关于益生菌预防新生儿NEC 的随机对
照试验(RCT),检索时限均为建库至2023 年4 月。由2 名评价者独立筛选文献、提取资料和评估方法学质量后,采用Stata 15. 1 SE
和RevMan 5. 4 软件进行Meta 分析。结果:最终纳入29 篇RCT,共6 354 例患儿。Meta 分析结果显示,预防性使用益生菌可显
著降低新生儿NEC 发生率(OR=0. 30,95%CI 0. 24~0. 37,P<0. 05)。共9 项RCT 提及NEC 相关病死率,预防性使用益生菌能
显著降低新生儿NEC 相关病死率(OR=0. 35,95%CI 0. 17~0. 70,P<0. 05)。结论:预防性使用益生菌可降低新生儿NEC 发生
风险和相关病死率。 |
| 关键词: 益生菌 新生儿 坏死性小肠结肠炎 Meta分析 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2024.05.009 |
|
| 基金项目:四川省科技计划项目,编号2021JDRC0161。 |
|
| Meta-Analysis on Efficacy of Probiotics in the Prevention of Neonatal Necrotizing Nterocolitis |
| Yang Qi1, Tang Lingling2, Li Run1, Jia JiaJia2, Chen Yalan2 |
| (1. The Affiliated Traditional Chinese Medicine Hospital of
Southwest Medical University, Sichuan Luzhou 646001, China; 2. Southwest Medical University, Sichuan Luzhou 646000, China) |
| Abstract: |
| Objective: To systematically review the efficacy and safety of probiotics in the prevention of neonatal necrotizing enterocolitis
(NEC). Methods: PubMed, EMBase, the Cochrane Library, Web of Science, CNKI, VIP, Wanfang and CBM were retrieved to
collect randomized controlled trials (RCT) of probiotics in the prevention of neonatal NEC. The retrieval time was from the establishment
of the databases to Apr. 2023. Meta-analysis was performed by using Stata 15. 1 SE and RevMan 5. 4 software after independent
selection of trials, extraction of information and assessment of methodological quality by two evaluators. Results: A total of 29 RCT were
enrolled, including 6,354 children. Meta-analysis showed that prophylactic use of probiotics significantly reduced the incidence of
neonatal NEC (OR=0. 30, 95% CI from 0. 24 to 0. 37, P<0. 05). NEC-related fatality was mentioned in 9 RCT, and prophylactic use
of probiotics significantly reduced neonatal NEC-related fatality (OR = 0. 35, 95% CI from 0. 17 to 0. 70, P <0. 05). Conclusion:
Prophylactic use of probiotics can reduce the risk of NEC and related fatality in neonates. |
| Key words: probiotics neonates necrotizing enterocolitis Meta-analysis |
