| 摘要: |
| 目的：观察匹多莫德防治脑性瘫痪（简称脑瘫）患儿反复呼吸道感染（RRI）的临床疗效及安全性。方法：将72例脑瘫合并RRI患儿随机分成观察组37例和对照组35例。两组患儿同时进行康复治疗，观察组加服匹多莫德每次400 mg，每天1次，持续服用60 d。观察两组患儿的临床症状，血清免疫球蛋白IgA、IgG、IgM水平，肝、肾功能，外周血象变化及可能出现的不良反应。结果：治疗后，观察组IgA、IgG水平比治疗前显著升高（P<0.05或P<0.01），但IgM与治疗前比较差异无统计学意义（P>0.05）；对照组IgA、IgG、IgM水平与治疗前比较差异均无统计学意义（均P>0.05）。与对照组比较，观察组呼吸道感染次数减少，发热时间、抗生素使用时间、咳嗽时间均缩短（P<0.05或P<0.01）。两组患儿治疗后BUN、ALT、WBC计数与治疗前比较差异均无统计学意义（P>0.05）。两组患儿不良反应发生率比较差异无统计学意义（P>0.05）。结论：匹多莫德用于防治脑瘫患儿RRI安全有效，值得临床推广应用。 |
| 关键词: 匹多莫德 脑性瘫痪 反复呼吸道感染 血清免疫球蛋白 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2016.03.009 |
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| 基金项目: |
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| Clinical Observation of Pidotimod on 72 Casees of Preventing Recurrent Respiratory Infections of the Children with Cerebral Palsy |
| Yang Enhua, Zuo Manfeng, Zhong Xin, Zheng Shenjian, Liu Jing, Luo Xiaomei |
| ((Xiaogan Central Hospital, Hubei Xiaogan 432000, China)) |
| Abstract: |
| Objective: To observe the clinical efficacy and safety of pidotimod on preventing recurrent respiratory infections of the children with cerebral palsy. Methods: The 72 children with cerebral palsy and recurrent respiratory infections were randomly divided into observtion group and control group. There are 37 children in observtion group and 35 children in control group. Everyone of the two groups was given rehabilitation treatment, at the same time, the children in observtion group were taken pidotimod, 400 mg/times, one times everyday for 60 days. Observe clinical symptoms, the level of serum immune globulin IgA, IgG, IgM, as well as the possible adverse effect. Results: After treatment,the amount of IgA, IgG except for IgM increased obviously in observtion group (P<0.05 or P<0.01). In comparison of the control group, the number of respiratory tract infection, the days of fever, antibiotic therapy and the days of cough in observtion group were significantly decreased, and the differences were statistically significant (P<0.05 or P<0.01). The incidence of adverse reactions between the two group was not statistically significant (P> 0.05). Conclusion: The effect of pidotimod on preventing recurrent respiratory infections of the children with cerebral palsy is good and safe. |
| Key words: Pidotimod Cerebral palsy Recurrent respiratory infections Serum immune globulin |
