| 摘要: |
| 目的：观察脑脊液和血清胰岛素样生长因子2（IGF-2）、肿瘤坏死因子（TNF-α）和白细胞计数（WBC）对化脓性脑膜炎（PM）的诊疗意义。方法：收集2010年2月至2014年5月在我院住院治疗的37例PM患儿，入院当天纳入急性期PM组，治疗后处于恢复期则作为恢复期PM组，选择同期不具有神经系统和系统感染性疾病的同期住院患儿28例为对照组。结果：PM组血清IGF-2水平较对照组低，TNF-α和WBC较对照组高（P均<0.05）；PM组脑脊液IGF-2、TNF-α、WBC和蛋白均较对照组高（P<0.05）。恢复期PM组血清IGF-2水平较急性期PM组显著增高（P<0.05），TNF-α和WBC较急性期PM组显著降低（P<0.05），脑脊液IGF-2、TNF-α水平较急性期PM组显著降低（P<0.05），WBC和蛋白与急性期PM组比较差异无统计学意义（P>0.05）。结论：TNF-α、WBC和蛋白可能参与了PM的损伤，IGF-2参与PM的保护，脑脊液的TNF-α、IGF-2、WBC和蛋白的联合检测在PM诊断、治疗和预后评估具有重要的临床意义。 |
| 关键词: 胰岛素样生长因子2 肿瘤坏死因子 白细胞计数 化脓性脑膜炎 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2016.01.002 |
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| 基金项目: |
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| The Clinic Significance of IGF-2, TNF-α and WBC in Cerebrospinal Fluid and Serum in Purulent Meningitis Children |
| Zhu Juan, Yan Jingjing, Qiao Jibing, Xu Lianbao |
| (Suqian City People’s Hospital of Nanjing Gulou Hospital Group, Jiangsu Suqian 223800, China) |
| Abstract: |
| Objective: To investigate the clinic significance of insulin-like growth factor 2 (IGF-2), tumor necrosis factor α (TNF-α) and white blood cell (WBC) in cerebrospinal fluid (CSF) and serum in purulent meningitis (PM) child patients. Methods: From February 2010 to May 2014, 37 cases of PM children patients in our hospital were enrolled into our study. 37 cases PM children patients before treatment were acute PM group, these patients after treatment were recovery PM group. 28 cases children who did no have central nervous system diseases as the control group. Results: Compared with the control group, IGF-2 was decreased, TNF-α and WBC were increased significantly in 2 PM groups (P<0.05). IGF-2, TNF-α, WBC and protein were increased in CSF (P<0.05). Compared with the acute PM group, IGF-2 was increased, TNF-α was decreased in serum, IGF-2 and TNF-α were decreased in CSF, but WBC and protein did no change in recovery PM group (P>0.05). Conclusion: TNF-α, WBC and protein may be involved in the development of PM. IGF-2 can protect PM. The detection of TNF-α, IGF-2, WBC and protein in cerebrospinal fluid, has important value in the diagnosis, treatment and prognosis of PM |
| Key words: insulin-like growth factor 2 tumor necrosis factor α white blood cell purulent meningitis |
