| 摘要: |
| 目的：探讨奥卡西平（OXC）单药治疗不同类型、不同年龄段儿童癫痫的长期疗效和安全性。方法：将32例学龄前期（2~6岁）和36例学龄期（>6~12岁）癫痫患儿根据脑电图检查结果和临床症状分为全面强直阵挛性发作（GTCS）、单纯部分性发作（SPS）、复杂部分性发作（CPS）和继发全面性强直阵挛性发作（SGTCS）四种发作类型，均应用OXC单药治疗。以治疗前3个月癫痫发作的平均频率作为基线，观察治疗后6、12、24个月时的疗效和安全性。结果：68例患儿失访4例，其余64例应用OXC单药治疗24个月后，总控制率和总有效率分别为59.38%和82.81%。随访64例患儿中，共有18例患儿发生不良反应/事件26例次，不良反应/事件总发生率28.13%（18/64）。OXC单药治疗GTCS、SPS、CPS和SGTCS的癫痫症状控制率、总有效率、不良反应/事件发生率比较差异均无统计学意义（P均>0.05）。学龄前期儿童组和学龄期儿童组的癫痫症状控制率比较差异无统计学意义（P>0.05），但总有效率分别为67.86%和94.44%（P<0.05），不良反应/事件发生率分别为42.86%和16.67%（P<0.05）。结论：OXC单药治疗GTCS、SPS、CPS和SGTC四种不同发作类型的癫痫患儿，具有相似的长期疗效和安全性，而且学龄期儿童的疗效和安全性优于学龄前期儿童。 |
| 关键词: 奥卡西平 癫痫 安全性 儿童 学龄期 学龄前 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2016.02.007 |
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| 基金项目: |
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| Clinical Analysis of Oxcarbazepine Monotherapy in Preschool and School-age Children with Different Forms of Epilepsy |
| Qiu Yanping |
| (Baoji Maternity and Child Health Care Hospital of Shaanxi Province, Shaanxi Baoji 721000, China) |
| Abstract: |
| Objective: To observe the long-term efficacy and safety of oxcarbazepine monotherapy in children depending on the patient’s age and form of epilepsy. Methods: 32 preschool children and 36 school-age children whom were identified with epilepsy and arranged to receive oxcarbazepine monotherapy were divided into the group of generalized tonic-clonic seizure (GTCS), the group of simple partial seizure (SPS), the group of complex partial seizure (CPS) and the group of secondary generalized tonic-clonic seizure (SGTCS) by the results of EEG and clinical symptoms. The average frequency of epileptic seizure of 3 months before treatment was regarded as the base line. To observe the clinical efficacy and safety 6 months, 12 months and 24 months after treatment. Results: After 24 months oxcarbazepine monotherapy, the general control rate and the general effective rate were of 59.38% and 82.81% respectively. There was no significant difference about control rates and incidences of adverse events in four different forms of epilepsy. But the total effective rats in four groups were 81.25%, 93.33%, 62.50% and 70.00%, respectively. The long-term efficacy in the SPS group was the best. There was no significant difference about control rates between preschool group and school-age group. The total effective rates of preschool group and school-age group were 67.86% and 94.44% respectively. The incidence of adverse events in preschool group was 42.86%, with 16.67% in the other group. Conclusion: The clinical efficiency and safety of oxcarbazepine monotherapy in four different forms of epilepsy were nearly. Oxcarbazepine monotherapy could applied in both partial seizure and generalized seizure. While it is more effective and safer in group than preschool group. |
| Key words: Oxcarbazepine Epilepsy Safety Children School-age Preschool |
